6344-28-1

Basic information

• Product Name: 2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone
• CAS NO: 6344-28-1
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.619
• Mol File: 6344-28-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 353.5°C at 760 mmHg
• Flash Point: 167.6°C
• Density: 1.296g/cm³
• Vapor Pressure: 1.75E-05mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone(6344-28-1)
• EPA Substance Registry System: 2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone(6344-28-1)

Safety Data

• Hazardous Substances Data: 6344-28-1(Hazardous Substances Data)

Usage

Description

2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone, also known as 2-chloro-4'-hydroxy-3'-methoxyacetophenone, is a chemical compound belonging to the class of organic compounds known as phenol ethers. It is a colorless to pale yellow liquid with a pleasant odor and is soluble in many organic solvents such as ethanol and acetone. Its unique chemical properties make it an important building block in the synthesis of various drugs and pharmaceuticals.

Uses

Used in Pharmaceutical Synthesis:
2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical properties. It serves as a building block for the development of new drugs and medicines.
Used in Skincare and Cosmetic Products:
2-chloro-1-(4-hydroxy-3-methoxyphenyl)ethanone is used as an antioxidant and anti-inflammatory agent in the development of skincare and cosmetic products. Its potential properties make it a valuable ingredient for creating effective formulations that can benefit the skin.

Upstream product

• 90-05-1 2-methoxy-phenol 
• 79-04-9 chloroacetyl chloride 
• 91-16-7 1,2-dimethoxybenzene 
• 160925-73-5 β-chloroacetoguaiacone acetate 
• 7647-01-0 hydrogenchloride 
• 50893-83-9 4-acetoxy-β-bromo-3-methoxyacetophenone 
• 54771-60-7 4-acetyl-2-methoxyphenyl acetate 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Downstream Products

• 113951-03-4 1-(4-hydroxy-3-methoxy-phenyl)-2-thiocyanato-ethanone 
• 139473-80-6 2-acetoxy-1-(4-hydroxy-3-methoxy-phenyl)-ethanone 
• 5653-20-3 3-(4-hydroxy-3-methoxy-phenyl)-3-oxo-propionitrile 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 91012-60-1 1-(4-hydroxy-3-methoxy-phenyl)-2-methylamino-ethanone 
• 1135683-19-0 C₁₅H₁₆N₂O₃S 
• 1616788-88-5 1-(4-benzyloxy-3-methoxyphenyl)-2-chloroethanone 
• 1266213-28-8 1-(4-benzyloxy-3-methoxyphenyl)-2-dimethylaminoethanone 
• 1616788-89-6 1-(4-benzyloxy-3-methoxyphenyl)-2-dimethylaminoethanol 
• 1616788-90-9 [2-(4-benzyloxy-3-methoxyphenyl)-2-phenoxyethyl]dimethylamine 
• 1616788-91-0 [2-(4-benzyloxy-3-methoxyphenyl)-2-phenoxyethyl]methylcarbamic acid ethyl ester 
• 1616788-92-1 C₂₆H₂₉NO₅ 
• 1616788-93-2 [2-(4-benzyloxy-3-methoxyphenyl)-2-(4-benzyloxyphenyl)ethyl]methylcarbamic acid ethyl ester 
• 1616788-94-3 [2-(4-benzyloxy-3-methoxyphenyl)-2-(4-benzyloxyphenyl)ethyl]methylamihe 

Relevant articles and documents

The α-chlorination of aryl methyl ketones under aerobic oxidative conditions

The novel reaction system air/ammonium nitrate/iodine/hydrochloric acid [air/NH4NO3(cat.)/I2(cat.)/HCl] is introduced as a simple, safe, cheap, efficient and regioselective mediator for the α-chlorination of aryl, heteroaryl and alkyl methyl ketones under aerobic oxidative conditions. The inventive use of a catalytic amount of iodine enabled the moderate to quantitative, regioselective chlorination of a comprehensive scope of different methyl ketone derivatives including those bearing oxidizable heteroatom (S, N) substituents, some of which possess declared potential biological and pharmaceutical activity. Air oxygen under a slight overpressure plays the role of the terminal oxidant catalytically activated by redox cycles of nitrogen oxides released from the catalytic amount of ammonium nitrate (NH4NO3) under acidic conditions of hydrochloric acid (HCl) and co-catalyzed by elemental iodine (I2), which was found to be essential for the high efficiency of the reaction system.

Preparation and properties of chlorinated syringic acids, acetosyringones, acetoguaiacones and methoxy-p-hydroquinones components of pulp bleaching effluents

A range of chlorinated phenols which serve as standards for compounds occurring in effluents from the bleaching of wood pulps with chlorine-containing reagents has been prepared. The chlorinated phenols include chlorosyringic acids, chloroacetosyringones, chloroacetoguaiacones, 5-chloro-2-methoxy-p-hydroquinone and chloro-2,6-dimethoxy-p-hydroquinones. With the exception of the ring-chlorinated acetoguaiacones which were prepared by reaction of chlorovanillin acetates with diazomethane, the compounds were obtained by direct chlorination of appropriate phenols or their acetates. Gas chromatographic and mass spectrometric data for the acetylated phenols are given.