6344-67-8 Usage
Description
3-Hydroxyfluorene, also known as fluoren-3-ol, is a monohydroxylated metabolite of polycyclic aromatic hydrocarbons (PAH). It is a chemical compound with the molecular formula C13H10O and a molecular weight of 182.22 g/mol. It has a planar structure with a hydroxyl group attached to the third carbon of the fluorene ring. 3-Hydroxyfluorene is a white crystalline solid that is soluble in organic solvents.
Uses
Used in Biomonitoring Applications:
3-Hydroxyfluorene is used as a biomarker for monitoring human exposure to polycyclic aromatic hydrocarbons (PAH). PAHs are a group of organic compounds that are formed during the incomplete burning of coal, oil, gas, wood, or other organic substances. They are found in air, water, and soil and can be harmful to human health. By measuring the levels of 3-hydroxyfluorene in urine, researchers can assess the extent of exposure to PAHs and evaluate the potential health risks associated with them.
Used in Environmental Analysis:
3-Hydroxyfluorene can also be used in environmental analysis to detect the presence of PAHs in various environmental samples, such as air, water, and soil. This information can help in understanding the distribution and sources of PAHs in the environment, as well as in developing strategies for reducing their exposure to humans and the environment.
Used in Toxicological Research:
3-Hydroxyfluorene can be used in toxicological research to study the effects of PAHs on human health. By investigating the metabolism and excretion of 3-hydroxyfluorene in humans, researchers can gain insights into the mechanisms of PAH toxicity and develop potential interventions to mitigate their harmful effects.
Used in Occupational Health:
3-Hydroxyfluorene can be used in occupational health to monitor the exposure of workers to PAHs in various industries, such as mining, construction, and manufacturing. By measuring the levels of 3-hydroxyfluorene in workers' urine, employers can assess the effectiveness of their safety measures and implement necessary changes to protect the health of their employees.
Check Digit Verification of cas no
The CAS Registry Mumber 6344-67-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,4 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6344-67:
(6*6)+(5*3)+(4*4)+(3*4)+(2*6)+(1*7)=98
98 % 10 = 8
So 6344-67-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H10O/c14-11-6-5-10-7-9-3-1-2-4-12(9)13(10)8-11/h1-6,8,14H,7H2
6344-67-8Relevant articles and documents
Method for reducing carbonyl reduction to methylene under illumination
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Paragraph 0033-0043, (2021/09/29)
The invention belongs to the technical field of organic chemical synthesis. The method comprises the following steps: (1) mixing the carbonyl compound and the amine compound in a solvent, reacting 3 - 6 under the illumination of 380 - 456 nm, the reaction system is low in toxicity, high in atom utilization rate 12 - 24h. and production efficiency, safe and controllable in reaction process and capable of simplifying the operation in the preparation and production process. At the same time, the residue toxicity of the reaction is minimized, the pollution caused by the production process to the environment is reduced, and the steps and operations of removing residues after the reaction are simplified. In addition, the reactant feedstock is readily available. The reactant does not need additional modification before the reaction, can be directly used for preparing production, simplifies the operation steps, and shortens the reaction route. The production cost is obviously reduced.
Formation of benzo-fused carbocycles by formal radical cyclization onto an aromatic ring
Clive, Derrick L. J.,Sunasee, Rajesh
, p. 2677 - 2680 (2008/02/09)
Equation Presented An indirect method for effecting radical carbocyclization onto aromatic rings is described. Cross-conjugated dienones such as 13, readily prepared by Birch reduction of aromatic fert-butyl esters, in situ alkylation, and oxidation (10 → 11 → 12 → 13), undergo radical cyclization; the products (14) are aromatized by silylation, Saegusa oxidation, and treatment with BiCl3·H2O. A noteworthy feature of this route is that it provides opportunities to attach an additional substituent to the original aromatic ring.
Studies under continuous irradiation of photochromic spiro [fluorenopyranthioxanthenes]
Salvador, Maria A.,Coelho, Paulo J.,Burrows, Hugh D.,Oliveira, M. Manuel,Carvalho, Luis M.
, p. 1400 - 1410 (2007/10/03)
New indeno-fused spiro[benzopyran-thioxanthenes] were synthesized (see 3a-d in Scheme3) and their photochromic properties evaluated under continuous irradiation (Table 1). When submitted to irradiation for several minutes with a Xe lamp, the system behaved as one constituted by two open colored forms with different thermal bleaching rates and different susceptibilities to degradation. An increase in irradiation time led to significant degradation and to the apparent predominance of the open colored form with the faster bleaching rate.
