6344-76-9

Basic information

• Product Name: 4-phenylsulfanylquinazoline
• Synonyms: 4-phenylsulfanylquinazoline
• CAS NO: 6344-76-9
• Molecular Formula: C₁₄H₁₀N₂S
• Molecular Weight: 238.31
• Mol File: 6344-76-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 414.5°C at 760 mmHg
• Flash Point: 204.5°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 1.07E-06mmHg at 25°C
• Refractive Index: 1.718
• CAS DataBase Reference: 4-phenylsulfanylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenylsulfanylquinazoline(6344-76-9)
• EPA Substance Registry System: 4-phenylsulfanylquinazoline(6344-76-9)

Safety Data

• Hazardous Substances Data: 6344-76-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H10N2S/c1-2-6-11(7-3-1)17-14-12-8-4-5-9-13(12)15-10-16-14/h1-10H

Upstream product

• 5190-68-1 4-chloroquinazoline 
• 108-98-5 thiophenol 
• 100-58-3 phenylmagnesium bromide 
• 21802-54-0 4-thiocyanatoquinazoline 
• 491-36-1 4-Hydroxyquinazoline 
• 897930-10-8 4-(1H-benzo[d][1,2,3]triazol-1-yloxy)quinazoline 
• 118-92-3 anthranilic acid 
• 491-36-1 4-quinazolinol 
• 1276665-99-6 C₈H₅Cl₅N₅OP₃ 

Downstream Products

• 5190-68-1 4-chloroquinazoline 

Relevant articles and documents

Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones

A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.

An efficient direct amination of cyclic amides and cyclic ureas

An efficient one-step amination of cyclic amides and ureas has been developed. Treatment of cyclic amides and cyclic ureas with BOP in the presence of DBU in various solvents led to the formation of cyclic amidines and cyclic guanidines in good to excellent yields. Concise syntheses of biologically intriguing kinetin and potent kinase inhibitor olomoucin were thus achieved in just one and two steps, respectively.

Quinazolines, their preparation and biological activity

-