6345-10-4

Basic information

• Product Name: (4-acetylphenyl)carbamoylformic acid
• Synonyms: (4-acetylphenyl)carbamoylformic acid
• CAS NO: 6345-10-4
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.18
• Mol File: 6345-10-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.393g/cm³
• Refractive Index: 1.618
• CAS DataBase Reference: (4-acetylphenyl)carbamoylformic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-acetylphenyl)carbamoylformic acid(6345-10-4)
• EPA Substance Registry System: (4-acetylphenyl)carbamoylformic acid(6345-10-4)

Safety Data

• Hazardous Substances Data: 6345-10-4(Hazardous Substances Data)

Usage

Description

(4-acetylphenyl)carbamoylformic acid is a chemical compound with the molecular formula C11H11NO4. It is a derivative of phenylcarbamoylformic acid and possesses a unique structure and functional groups. This versatile compound is used in organic synthesis as a reagent for the preparation of various organic compounds and has potential applications in pharmaceuticals and agrochemicals due to its cytotoxic and antiproliferative properties.

Uses

Used in Organic Synthesis:
(4-acetylphenyl)carbamoylformic acid is used as a reagent in organic synthesis for the preparation of various organic compounds. Its unique structure and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
(4-acetylphenyl)carbamoylformic acid is used as a potential candidate in pharmaceutical research for its cytotoxic and antiproliferative properties. Its structural features and functional groups make it a promising compound for the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
(4-acetylphenyl)carbamoylformic acid is used as a potential candidate in agrochemical research for its potential applications in the development of new pesticides, herbicides, and other agrochemical products. Its unique structure and functional groups may contribute to the creation of innovative and effective solutions in agriculture.

InChI:InChI=1/C10H9NO4/c1-6(12)7-2-4-8(5-3-7)11-9(13)10(14)15/h2-5H,1H3,(H,11,13)(H,14,15)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 6345-12-6 N-(4-acetyl-phenyl)-ethyl oxalate 

Downstream Products

• 85849-73-6 N-{4-[4-(Oxalyl-amino)-phenyl]-thiazol-2-yl}-oxalamic acid 
• 1375736-82-5 N¹-(4-acetylphenyl)-N²-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride 

Relevant articles and documents

Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1

The CD4 binding site on HIV-1 gp120 has been validated as a drug target to prevent HIV-1 entry to cells. Previously, we identified two small molecule inhibitors consisting of a 2,2,6,6-tetramethylpiperidine ring linked by an oxalamide to a p-halide-substituted phenyl group, which target this site, specifically, a cavity termed "Phe43 cavity". Here we use synthetic chemistry, functional assessment, and structure-based analysis to explore variants of each region of these inhibitors for improved antiviral properties. Alterations of the phenyl group and of the oxalamide linker indicated that these regions were close to optimal in the original lead compounds. Design of a series of compounds, where the tetramethylpiperidine ring was replaced with new scaffolds, led to improved antiviral activity. These new scaffolds provide insight into the surface chemistry at the entrance of the cavity and offer additional opportunities by which to optimize further these potential-next- generation therapeutics and microbicides against HIV-1.