63463-20-7

Basic information

• Product Name: 3-Quinolinecarboxylicacid,7-fluoro-4-hydroxy-(9CI)
• Synonyms: 3-Quinolinecarboxylicacid,7-fluoro-4-hydroxy-(9CI);7-fluoro-4-hydroxy-3-Quinolinecarboxylic acid
• CAS NO: 63463-20-7
• Molecular Formula: C₁₀H₆FNO₃
• Molecular Weight: 207.159
• Product Categories: QUINOLINE
• Mol File: 63463-20-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 358.5°C at 760 mmHg
• Flash Point: 170.6°C
• Appearance: /
• Density: 1.517g/cm³
• Vapor Pressure: 9.17E-06mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 3-Quinolinecarboxylicacid,7-fluoro-4-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylicacid,7-fluoro-4-hydroxy-(9CI)(63463-20-7)
• EPA Substance Registry System: 3-Quinolinecarboxylicacid,7-fluoro-4-hydroxy-(9CI)(63463-20-7)

Safety Data

• Hazardous Substances Data: 63463-20-7(Hazardous Substances Data)

Usage

General Description

3-Quinolinecarboxylic acid, 7-fluoro-4-hydroxy-(9CI), also known as 7-Fluoro-4-hydroxyquinoline-3-carboxylic acid, is a chemical compound with the molecular formula C10H6FNO3. It is a derivative of quinolinecarboxylic acid and features a fluorine atom and a hydroxy group attached to the quinoline ring. 3-Quinolinecarboxylicacid,7-fluoro-4-hydroxy-(9CI) has potential biological activity and may be used as a building block in pharmaceutical and agrochemical research. Its properties and potential applications make it a compound of interest for further study and development.

InChI:InChI=1/C10H6FNO3/c11-5-1-2-6-8(3-5)12-4-7(9(6)13)10(14)15/h1-4H,(H,12,13)(H,14,15)

Upstream product

• 26892-97-7 ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate 
• 372-19-0 meta-fluoroaniline 
• 26832-95-1 diethyl 2-(((3-fluorophenyl)amino)methylene)malonate 
• 26892-97-7 7-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester 
• 53977-49-4 1-ethyl-1,4-dihydro-7-fluoro-4-oxoquinoline-3-carboxylic acid 
• 213454-52-5 1-Ethyl-4-[(E)-ethylimino]-7-fluoro-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 216986-62-8 1-ethyl-4-ethylimino-7-fluoro-1,4-dihydroquinoline-3-carboxylic acid 
• 216986-75-3 4-cyclopropylimino-1-ethyl-7-fluoro-1,4-dihydroquinoline-3-carboxylic acid 
• 1583-58-0 2,4-difluoro-benzoic acid 

Downstream Products

• 391-83-3 7-fluoro-1,4-dihydroquinolin-4-one 
• 391-83-3 7-fluoro-4-hydroxyquinoline 
• 391-82-2 4-Chloro-7-fluoroquinoline 
• 1134061-59-8 4-hydroxy-7-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}quinoline-3-carboxylic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents

A series of new quinoline derivatives was designed, synthesized and evaluated for their antiproliferative activity. The results demonstrated that compounds 11p, 11s, 11v, 11x and 11y exhibited potent antiproliferative activity with IC50 value of lower than 10 μM against seven human tumor cell lines, and N-(3-methoxyphenyl)-7- (3-phenylpropoxy)quinolin-4-amine 11x was found to be the most potent antiproliferative agent against HCT-116, RKO, A2780 and Hela cell lines with an IC50 value of 2.56, 3.67, 3.46 and 2.71 μM, respectively. The antitumor efficacy of the representative compound 11x in mice was also evaluated, and the results showed that compound 11x effectively inhibited tumor growth and decreased tumor weight in animal models. Further investigation on mechanism of action indicated that compound 11x could inhibit colorectal cancer growth through ATG5-depenent autophagy pathway. Therefore, these quinoline derivatives are a new class of molecules that have the potential to be developed as new antitumor drugs.

For antibacterial chlorine oxygen kui derivatives

The invention relates to an oxo-quinoline derivative with activity of resisting bacterial infection relevant diseases such as helicobacter pylori (Hp) infection disease. The invention specifically relates to a compound as shown in formula I in the specification, and a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R is selected from hydrogen, -C alkyl, -C alkenyl, -C alkynyl, or -C alkyl-phenyl, and the alkyl, alkenyl, alkynyl and phenyl can be randomly substituted by halogen, nitro, cyan, hydroxyl, -C alkoxy and phenyl; R is selected from hydrogen, -CONHR and -COOR, R and R are independently selected from -C alkyl and -C alkyl amino, and the amino is randomly substituted by one to two -C alkyls; R is selected from halogen, -C alkoxy, morpholinyl or piperazinyl.

Synthesis and anti-tumor activities of 4-anilinoquinoline derivatives

Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a-g; 2c; 2e and 2i) exhibited excellent antitumor activity superior to that of gefitinib. Among the ten compounds; seven (1a-c; 1e-1g and 2i) displayed excellent selectivity for BGC823 cells. In particular; 1f and 2i exhibited potent cytotoxic activities against HeLa cells and BGC823 cells with better IC50 values than gefitinib.