63469-49-8

Basic information

• Product Name: 1-IODO-5-METHOXYNAPHTHALENE
• Synonyms: 1-IODO-5-METHOXYNAPHTHALENE;Naphthalene, 1-iodo-6-methoxy- (9CI)
• CAS NO: 63469-49-8
• Molecular Formula: C₁₁H₉IO
• Molecular Weight: 284.09
• Product Categories: NAPHTALENE
• Mol File: 63469-49-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.674
• CAS DataBase Reference: 1-IODO-5-METHOXYNAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-IODO-5-METHOXYNAPHTHALENE(63469-49-8)
• EPA Substance Registry System: 1-IODO-5-METHOXYNAPHTHALENE(63469-49-8)

Safety Data

• Hazardous Substances Data: 63469-49-8(Hazardous Substances Data)

Usage

General Description

1-Iodo-5-methoxynaphthalene is a chemical compound with the molecular formula C11H9IO. It is an iodinated derivative of 5-methoxynaphthalene and is commonly used in research and industrial applications. 1-IODO-5-METHOXYNAPHTHALENE is known for its high reactivity due to the presence of the iodine atom, which makes it a versatile building block for the synthesis of various organic molecules. 1-Iodo-5-methoxynaphthalene has been used in the development of pharmaceuticals, agrochemicals, and materials science. It is also employed as a starting material for the synthesis of more complex organic compounds. Due to its reactivity and unique properties, 1-Iodo-5-methoxynaphthalene is a valuable compound in the field of organic chemistry.

Upstream product

• 5302-77-2 6-methoxynaphthylamine 
• 128542-67-6 C₁₅H₁₉N₃O 
• 412041-55-5 ((4-methoxy-1,2-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) 
• 607-45-4 5-Nitro-2-naphthol 
• 31199-12-9 2-Methoxy-5-nitronaphthalene 
• 607-44-3 2-amino-5-nitronaphthalene 
• 5400-20-4 N-(6-hydroxy-[1]naphthyl)-acetamide 
• 55346-60-6 N-(6-methoxy-[1]naphthyl)-acetamide 

Downstream Products

• 107419-52-3 methyl-[5-(2-nitro-phenyl)-[2]naphthyl]-ether 
• 77029-01-7 6-methoxy-[1]naphthonitrile 
• 3597-42-0 6-methoxy-1-naphthalaldehyde 
• 848073-48-3 1-(4-methoxyphenyl)-2-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1-(6-methoxynaphthalen-1-yl)propene 
• 571206-45-6 6-hydroxy-1-naphthaldehyde 
• 2437-17-4 6-hydroxy-1-naphthoic acid 

Relevant articles and documents

Regioselective haloaromatization of 1,2-bis(ethynyl)benzene via halogen acids and PtCl2. Platinum-catalyzed 6-π electrocyclization of 1,2-bis(1′-haloethenyl)benzene intermediates

Treatment of 1,2-bis(ethynyl)benzene (1) with aqueous HX (X = Br, I) in hot 3-pentanone (100-105 °C, 2 h) afforded 1,2-bis(1′-haloethenyl)benzene species 2-Br and 2-I in 98% and 95% yields, respectively. The hydrochlorination of endiyne 1 failed to proceed at elevated temperature but was implemented efficiently by PtCl2 (5 mol %) in hot 3-pentanone (100 °C, 2 h) to give 1,2-bis(1′-chloroetheny)benzene 2-Cl in 80% yield. In the presence of PtCl2 (5 mol %), these halides 2-Cl, 2-Br, and 2-I were subsequently converted to 1-halonaphthalenes 3-Cl, 3-Br, and 3-I in the mother solution via sequential 6-π electrocyclization and dehalogenation reactions. PtCl2 (5 mol %) also effected direct haloaromatization of endiyne 1 with HX (X = Cl, Br, I) and gave 1-halonaphthalenes 3-Cl, 3-Br, and 3-I in 64-71% yields. This investigation reports the scope and the regioselectivity of haloaromatization of various enediynes catalyzed by PtCl2.