63477-43-0

Basic information

• Product Name: 1-(benzhydrylaMino)-3-chloropropan-2-ol
• Synonyms: 1-(benzhydrylaMino)-3-chloropropan-2-ol;1-Chloro-3-[(diphenylmethyl)amino]-2-propanol
• CAS NO: 63477-43-0
• Molecular Formula: C₁₆H₁₈ClNO
• Molecular Weight: 275.77322
• Mol File: 63477-43-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 201 °C
• Boiling Point: 431.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.162
• PKA: 13.57±0.20(Predicted)
• CAS DataBase Reference: 1-(benzhydrylaMino)-3-chloropropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzhydrylaMino)-3-chloropropan-2-ol(63477-43-0)
• EPA Substance Registry System: 1-(benzhydrylaMino)-3-chloropropan-2-ol(63477-43-0)

Safety Data

• Hazardous Substances Data: 63477-43-0(Hazardous Substances Data)

Usage

General Description

1-(benzhydrylaMino)-3-chloropropan-2-ol is a chemical compound that contains a benzhydrylamine group and a chloropropan-2-ol group. It is commonly used as a precursor for the synthesis of pharmaceuticals and other organic compounds. The compound has been found to possess antihistaminic and anticholinergic properties, making it potentially useful for the treatment of allergies and other medical conditions. Additionally, it is known to have some sedative and anxiolytic effects, which could make it useful in the treatment of anxiety and related disorders. Overall, 1-(benzhydrylaMino)-3-chloropropan-2-ol is an important intermediate in organic synthesis and has potential therapeutic applications in the field of medicine.

Upstream product

• 91-00-9 Benzhydrylamine 
• 106-89-8 epichlorohydrin 

Downstream Products

• 90604-02-7 1-(diphenylmethyl)-3-azetidinol hydrochloride 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 63477-45-2 3-diphenylmethyl-5-chloromethyloxazolidine 
• 1218777-32-2 5-((benzhydrylamino)methyl)oxazolidin-2-one 
• 55438-79-4 3-(dimethylamino)-1-(diphenylmethyl)azetidine 
• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 40432-52-8 1-benzhydrylazetidin-3-ylamine 
• 143699-92-7 3-Azido-1-benzhydryl-azetidine 

Relevant articles and documents

Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER

The present invention relates to certain 2-(2,4,5-substituted-anilino) pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

DMAP-catalyzed synthesis of 2-oxazolidinones from corresponding halohydrins using KOCN/DMF

We report facile and simple synthesis of a variety of 2-oxazolidinones from the corresponding halohydrins by reaction with KOCN in DMF catalyzed by DMAP. DMAP and temperature play key roles in enriching the yield of 2-oxazolidinones. A few examples in this Letter are applicable to pharmaceutically important processes.