63485-25-6

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[(4-hydroxy-3,5-dimethylphenyl)methyl]-
• CAS NO: 63485-25-6
• Molecular Formula: C17H15NO3
• Molecular Weight: 281.311
• Mol File: 63485-25-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-hydroxy-3,5-dimethylphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-hydroxy-3,5-dimethylphenyl)methyl]-(63485-25-6)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[(4-hydroxy-3,5-dimethylphenyl)methyl]-(63485-25-6)

Safety Data

• Hazardous Substances Data: 63485-25-6(Hazardous Substances Data)

Upstream product

• 136918-14-4 phthalimide 
• 527-60-6 Mesitol 
• 576-26-1 2.6-dimethylphenol 
• 4513-31-9 N-(N',N'-diethylaminomethyl)phthalimide 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 876-15-3 4-(aminomethyl)-2,6-dimethylphenol 

Relevant articles and documents

Chemoselective oxidative generation of ortho-quinone methides and tandem transformations

ortho-Quinone methides are useful transient synthetic intermediates in organic synthesis. These species are most often generated in situ by the acid- or base-mediated transformation of phenols that have been pre-functionalized at a benzylic position, or by biomimetic oxidation of the corresponding ortho-alkylphenols with metal oxidants or transition-metal complexes. Here we describe a method for the transition-metal-free oxidative generation of o-QMs from ortho-alkylarenols, using hypoiodite catalysis under nearly neutral conditions, which can then be applied in one-pot tandem reactions. This method for the chemoselective oxidative generation of ortho-quinone methides may prove superior to previous methods with respect to environmental issues and scope, and can be applied to various tandem reactions such as inter- or intramolecular [4 + 2] cycloaddition, oxa-6π-electrocyclization, conjugate addition and spiroepoxidation. [Figure not available: see fulltext.].

Selective copper(II)-mediated oxidative coupling of a nucleophilic reagent to the para-methyl group of 2,4,6-trimethylphenol

A copper(II) neocuproine system has been developed for the efficient and very selective 1,6-addition of a nucleophile to the para-methyl group of 2,4,6-trimethylphenol. Crystallographic and spectroscopic data point towards the involvement of a μ-methoxo-μ-phenoxo-bridged copper species which appears to generate a highly reactive quinone methide intermediate that can be attacked by a nucleophilic reagent. The Royal Society of Chemistry 2005.