634920-02-8

Basic information

• Product Name: 4-thiophen-2-ylmethyl-oxazolidine-2,5-dione
• Synonyms: 4-thiophen-2-ylmethyl-oxazolidine-2,5-dione
• CAS NO: 634920-02-8
• Molecular Weight: 197.214
• Mol File: 634920-02-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-thiophen-2-ylmethyl-oxazolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-thiophen-2-ylmethyl-oxazolidine-2,5-dione(634920-02-8)
• EPA Substance Registry System: 4-thiophen-2-ylmethyl-oxazolidine-2,5-dione(634920-02-8)

Safety Data

• Hazardous Substances Data: 634920-02-8(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 2021-58-1 rac-3-(2-thienyl)alanine 

Downstream Products

• 146923-55-9 (2S)-3-(thien-2-yl)-2-(benzyloxycarbonylamino)propionic acid 
• 117467-72-8 (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)propanoic acid 
• 394210-39-0 2,5-dioxo-4-thiophen-2-ylmethyl-oxazolidine-3-carboxylic acid benzyl ester 

Relevant articles and documents

Dynamic Kinetic Resolution for Asymmetric Synthesis of α-Alkyl Amino Acids via Dual-Function Catalysis of Modified Cinchona Alkaloids

The electronic property of the N-protecting group of N-carboxyanhydrides (NCA) is found to have a significant influence on the rate of racemization of NCA with modified cinchona alkaloids. Consequently, modified cinchona alkaloids can be applied as dual-function catalysts to catalyze both the racemization and alcoholytic kinetic resolution of alkyl NCA bearing an electron-withdrawing N-protecting group, leading to a dynamic kinetic resolution converting racemic alkyl NCAs to the corresponding amino esters in 59-75% ee and 75-87% yield. Upon recrystallization, the amino ester can be obtained in greater than 99% ee and 53% yield from the racemic NCA.