634926-63-9 Usage
Description
Carbamic acid, [2-(2-propynyloxy)ethyl]-, 1,1-dimethylethyl ester (9CI), also known as tert-Butyl (2-(prop-2-yn-1-yloxy)ethyl)carbamate, is a crosslinker that consists of a propargyl group and a t-Boc protected amine group. Carbamic acid, [2-(2-propynyloxy)ethyl]-, 1,1-dimethylethyl ester (9CI) is designed to facilitate chemical reactions and bonding between various molecules, particularly through the use of its unique functional groups.
Uses
Used in Chemical Synthesis:
Carbamic acid, [2-(2-propynyloxy)ethyl]-, 1,1-dimethylethyl ester (9CI) is used as a crosslinker in chemical synthesis for the formation of new compounds and materials. The propargyl group in this molecule allows it to react with azide-bearing compounds or biomolecules via copper-catalyzed Click Chemistry reactions, enabling the creation of a wide range of products with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Carbamic acid, [2-(2-propynyloxy)ethyl]-, 1,1-dimethylethyl ester (9CI) is used as a key intermediate in the synthesis of various drugs and drug candidates. The t-Boc protected amine group can be deprotected under mild acidic conditions, allowing for further modification and functionalization of the molecule, which can be crucial in the development of new therapeutic agents.
Used in Bioconjugation:
Carbamic acid, [2-(2-propynyloxy)ethyl]-, 1,1-dimethylethyl ester (9CI) is also used in bioconjugation, a process that involves the attachment of biologically active molecules to other molecules, such as drugs, dyes, or detection agents. The propargyl group in this compound can react with azide-bearing biomolecules, allowing for the formation of stable covalent bonds and the creation of bioconjugates with potential applications in research, diagnostics, and therapeutics.
Used in Material Science:
In the field of material science, Carbamic acid, [2-(2-propynyloxy)ethyl]-, 1,1-dimethylethyl ester (9CI) can be used as a building block for the development of novel materials with specific properties. The ability of this compound to participate in Click Chemistry reactions and form stable bonds with a variety of molecules makes it a valuable tool for the design and synthesis of advanced materials with tailored characteristics for various applications, such as sensors, catalysts, or drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 634926-63-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,4,9,2 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 634926-63:
(8*6)+(7*3)+(6*4)+(5*9)+(4*2)+(3*6)+(2*6)+(1*3)=179
179 % 10 = 9
So 634926-63-9 is a valid CAS Registry Number.
634926-63-9Relevant articles and documents
Novel camptothecin derivative, and preparation method and application thereof
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, (2020/03/12)
The invention relates to a novel camptothecin derivative and application thereof, a tumor cell growth inhibitor, a ternary complex, and a method for improving the solubility of the camptothecin derivative. The camptothecin derivative is formed by modifying a substance represented by formula I through glycosylated triazole in the position R3. In a structural formula represented by the formula I, R1represents H, alkyl of C1-10, deuterated alkyl of the C1-10, or halogenated alkyl of the C1-10; R2 represents H, CH2N(CH3)2 or CH2N(CD3)2; R4 represents H, and X represents N, O or S; L represents polypeptide, C1-20 linear alkyl or a derivative thereof, a C1-20 linear or branched acyl derivative, or C2-100 ethylene glycol or a derivative thereof. The camptothecin derivative has high solubility, prepared anticancer drugs have the advantages of wide anticancer spectrum and high safety, and the in-vivo anticancer activity is superior to that of irinotecan hydrochloride.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 2386; 2387, (2019/07/10)
The present invention provides compounds, compositions thereof, and methods of using the same.
Catalytic Asymmetric Synthesis of Morpholines. Using Mechanistic Insights to Realize the Enantioselective Synthesis of Piperazines
Lau, Ying Yin,Zhai, Huimin,Schafer, Laurel L.
, p. 8696 - 8709 (2016/10/14)
An efficient and practical catalytic approach for the enantioselective synthesis of 3-substituted morpholines through a tandem sequential one-pot reaction employing both hydroamination and asymmetric transfer hydrogenation reactions is described. Starting from ether-containing aminoalkyne substrates, a commercially available bis(amidate)bis(amido)Ti catalyst is utilized to yield a cyclic imine that is subsequently reduced using the Noyori-Ikariya catalyst, RuCl [(S,S)-Ts-DPEN] (η6-p-cymene), to afford chiral 3-substituted morpholines in good yield and enantiomeric excesses of >95%. A wide range of functional groups is tolerated. Substrate scope investigations suggest that hydrogen-bonding interactions between the oxygen in the backbone of the ether-containing substrate and the [(S,S)-Ts-DPEN] ligand of the Ru catalyst are crucial for obtaining high ee's. This insight led to a mechanistic proposal that predicts the observed absolute stereochemistry. Most importantly, this mechanistic insight allowed for the extension of this strategy to include N as an alternative hydrogen bond acceptor that could be incorporated into the substrate. Thus, the catalytic, enantioselective synthesis of 3-substituted piperazines is also demonstrated.