63518-24-1

Basic information

• Product Name: 4β-Hydroxy DHEA (available to WADA laboratories only)
• Synonyms: 4β-Hydroxy DHEA (available to WADA laboratories only);3β,4β-Dihydroxyandrost-5-en-17-one;(3S,4R,8R,9S,10R,13S,14S)-3,4-dihydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
• CAS NO: 63518-24-1
• Molecular Formula: C19H28O3
• Molecular Weight: 304.42382
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 63518-24-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 198-200 °C
• Boiling Point: 451.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.30±0.70(Predicted)
• CAS DataBase Reference: 4β-Hydroxy DHEA (available to WADA laboratories only)(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-Hydroxy DHEA (available to WADA laboratories only)(63518-24-1)
• EPA Substance Registry System: 4β-Hydroxy DHEA (available to WADA laboratories only)(63518-24-1)

Safety Data

• Hazardous Substances Data: 63518-24-1(Hazardous Substances Data)

Upstream product

• 50633-63-1 4β-acetoxy-3β-hydroxyandrost-5-en-17-one 
• 50633-62-0 3β,4β-diacetoxyandrost-5-en-17-one 
• 53-43-0 dehydroepiandrosterone 
• 29163-23-3 3β-formyl-oxy-5-androsten-17-one 
• 51104-94-0 3β-bromoandrost-5-en-17-one 
• 897-01-8 (3S,8R,9S,10R,13S,14S)-3-Chloro-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one 
• 853-23-6 prasterone acetate 
• 86270-34-0 4β-hydroxy-3β-acetoxy-androsten-(5)-one-(17) 

Downstream Products

• 86270-41-9 3β-ethoxycarbonyloxy-4β-hydroxyandrost-5-en-17-one 
• 21358-93-0 4β-hydroxy-3β-p-tolylsulphonyloxyandrost-5-en-17-one 

Relevant articles and documents

Syntheses of (E)- and (Z)-volkendousin

The first syntheses of the antitumor agents (E)-volkendousin (1) and acetonide 3 have been accomplished by efficient routes from readily available dehydroisoandrosterone (7) using allylic oxidation with SeO2 to introduce the 4β-hydroxy group and 16- ketone. This sequence should make these compounds readily available for further biological evaluation.

Allylic Acetoxylation of Δ5-Steroids at C-4

The allylic acetoxylation of Δ5-steroids at C-4 by reaction with bromine and silver acetate has been shown to depend upon the nature of the C-3 substituent. 2H Labelling studies have shown that the reaction, which proceeds via the 5α,6β-dibromide, involves the trans diaxial elimination of a 4β-proton to form a Δ4-6β-bromide which then undergoes an SN2' displacement by the incoming acetate assisted by the silver ion.