63558-77-0

Basic information

• Product Name: 2,4-Dichloro-5-phenylpyriMidine
• Synonyms: 2,4-Dichloro-5-phenylpyriMidine
• CAS NO: 63558-77-0
• Molecular Formula: C₁₀H₆Cl₂N₂
• Molecular Weight: 225.07404
• Mol File: 63558-77-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 78-80 °C
• Boiling Point: 181-182 °C(Press: 16 Torr)
• Appearance: /
• Density: 1.363±0.06 g/cm3(Predicted)
• PKA: -3.13±0.29(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-5-phenylpyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-phenylpyriMidine(63558-77-0)
• EPA Substance Registry System: 2,4-Dichloro-5-phenylpyriMidine(63558-77-0)

Safety Data

• Hazardous Substances Data: 63558-77-0(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-5-phenylpyrimidine is a chemical compound with the molecular formula C10H6Cl2N2. It is a white solid with a molecular weight of 217.07 g/mol. 2,4-Dichloro-5-phenylpyriMidine is widely used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical intermediates. It has also been studied for its potential anti-cancer and anti-inflammatory properties. Additionally, 2,4-Dichloro-5-phenylpyrimidine is used as a reagent in organic synthesis and as a key component in the production of agrochemicals. Overall, this compound has various important applications in the fields of medicine and agriculture.

Upstream product

• 15761-83-8 5-phenyluracil 
• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 39860-32-7 2-chloro-4,5-diphenylpyrimidine 
• 685866-82-4 (2-chloro-5-phenyl-pyrimidin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine 

Relevant articles and documents

Regioselective 2-Amination of Polychloropyrimidines

The regioselective amination of substituted di- and trichloropyrimidines affording the 2-substituted products is reported. While aryl- and heteroarylamines require the use of a dialkylbiarylphosphine-derived palladium catalyst for high efficiency, more nucleophilic dialkylamines produce 2-aminopyrimidines under noncatalyzed SNAr conditions. The key is the use of 5-trimethylsilyl-2,4-dichloropyrimidine as a surrogate for the parent dichloropyrimidine. For more challenging cases, the 2-chloro-4-thiomethoxy analogues were prepared and exclusively afford the desired 2-aminated-4-thiomethoxypyrimidine products.

PYRIMIDINE DERIVATIVES

The present invention provides a pyrimidine derivative represented by Formula (I) [wherein Ar represents substituted or unsubstituted aryl, etc., R1 represents -NR2R3 (wherein R2 represents a hydrogen atom or su