635727-03-6Relevant articles and documents
Stereoselective total synthesis of the natural (+)-lasonolide A
Kang, Sung Ho,Kang, Suk Youn,Choi, Hyeong-Wook,Kim, Chul Min,Jun, Hyuk-Sang,Youn, Joo-Hack
, p. 1102 - 1114 (2007/10/03)
The natural (+)-lasonolide A (1), an anti-tumor agent, has been synthesized via thermodynamic benzylidene formation at the C22 quaternary chiral center, use of a disulfone equivalent for elongation of the C 15-C17 three-carbon chain as well as introduction of the two trans olefins at C15 and C17, iodocyclization for the upper THP, Michael addition for the bottom THP, and intramolecular Horner-Emmons olefination for the 20-membered macrolactone.