635752-88-4Relevant articles and documents
A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines
Tollefson, Michael B.,Kolodziej, Stephen A.,Fletcher, Theresa R.,Vernier, William F.,Beaudry, Judith A.,Keller, Bradley T.,Reitz, David B.
, p. 3727 - 3730 (2007/10/03)
A series of 5-aryl-3,3-dibutyl-7-(dimethylamino)-1,2-benzothiazepin-4-ol 1,1-dioxides were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT) for the potential treatment for hyperlipidemia. Several 1,2-benzothiazepines exhibited low nanomolar in vitro activity. The synthesis and initial in vitro potency data is presented for this novel class of compounds.