6358-26-5 Usage
General Description
4-[(9-ethyl-9H-carbazol-3-yl)amino]phenol, also known as PR-619, is a chemical compound that belongs to the class of phenols. It is a potent and selective inhibitor of the deubiquitinating enzyme (DUB) family of enzymes, which play a crucial role in the regulation of protein degradation and turnover in cells. PR-619 has been widely used in research studies to investigate the role of DUBs in various cellular processes, including DNA damage response, inflammation, and cancer development. Its unique structure, containing a carbazole group, makes it an attractive candidate for the development of new therapeutics targeting DUBs. Additionally, PR-619 has shown potential as an anti-inflammatory and anticancer agent in preclinical studies. Further research is needed to fully understand its biological activities and therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 6358-26-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,5 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6358-26:
(6*6)+(5*3)+(4*5)+(3*8)+(2*2)+(1*6)=105
105 % 10 = 5
So 6358-26-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H18N2O/c1-2-22-19-6-4-3-5-17(19)18-13-15(9-12-20(18)22)21-14-7-10-16(23)11-8-14/h3-13,21,23H,2H2,1H3
6358-26-5Relevant articles and documents
Process for the preparation of derivatives of 3-(4-hydroxy-anilino)carbazole
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, (2008/06/13)
The process for the preparation of a 3-(4-hydroxyanilino)carbazole of the formula STR1 wherein R is hydrogen, alkyl having 1 to 8 carbon atoms or halogenoalkyl having 1 to 8 carbon atoms, comprising reacting a 3-aminocarbazole of the formula STR2 with p-hydroquinone or p-aminophenol or a mixture of p-hydroquinone and p-aminophenol in at least stoichiometric amounts by heating to a temperature of 150° to 300° C. with exclusion of oxygen.
