63598-71-0

Basic information

• Product Name: 1H-1,2,4-triazole
• CAS NO: 63598-71-0
• Molecular Formula: C2H3N3
• Molecular Weight: 69.07
• Mol File: 63598-71-0.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-triazole(63598-71-0)
• EPA Substance Registry System: 1H-1,2,4-triazole(63598-71-0)

Safety Data

• Hazardous Substances Data: 63598-71-0(Hazardous Substances Data)

Usage

Chemical structure

1H-1,2,4-triazole is a heterocyclic organic compound with a five-membered ring consisting of three nitrogen atoms and two carbon atoms.

Physical state

It is a clear, colorless liquid.

Applications in pharmaceutical industry

Widely used as a building block for the synthesis of various drugs and pharmaceutical compounds.

Applications in agriculture

Used as a fungicide.

Applications in polymer and plastic production

Utilized in the production of polymers and plastics.

Use as a stabilizer

Employed as a stabilizer for peroxide-based compounds.

Use as a corrosion inhibitor

Acts as a corrosion inhibitor.

Unique structure

1H-1,2,4-triazole has a unique structure that contributes to its versatile properties.

Importance in various industries

Due to its versatile properties, 1H-1,2,4-triazole is an important chemical compound in the pharmaceutical, agricultural, polymer, and corrosion inhibition industries.

Upstream product

• 288-88-0 1,2,4-Triazole 
• 584-13-4 4-amino-1,2,4-triazole 
• 108-67-8 1,3,5-trimethyl-benzene 
• 122709-89-1 Phenyl-[(Z)-[1,2,4]triazol-4-ylimino]-acetic acid 
• 24994-60-3 1-amino-1,2,4-triazole 
• 98-88-4 benzoyl chloride 
• 1015603-47-0 5-benzoyl-3-ethoxycarbonyl-1-methyl-6-methylthio-1,2-dihydropyridin-2-one 

Downstream Products

• 122583-48-6 1-Benzylideneamino-1H-1,2,4-triazole 
• 72796-81-7 2-(Diethoxy-phosphoryl)-3-p-tolyl-3-[1,2,4]triazol-1-yl-propionic acid ethyl ester 
• 72796-75-9 2-[(4-Chloro-phenyl)-[1,2,4]triazol-1-yl-methyl]-3-oxo-butyric acid ethyl ester 
• 72796-74-8 3-(4-Chloro-phenyl)-2-dimethylcarbamoyl-3-[1,2,4]triazol-1-yl-propionic acid methyl ester 
• 72811-86-0 2-(4-Chloro-benzoyl)-3-phenyl-3-[1,2,4]triazol-1-yl-propionic acid methyl ester 
• 72796-83-9 4-(4-Chloro-phenyl)-3-(toluene-4-sulfonyl)-4-[1,2,4]triazol-1-yl-butan-2-one 
• 72796-82-8 3-(4-Chloro-phenyl)-2-(toluene-4-sulfonyl)-3-[1,2,4]triazol-1-yl-propionic acid methyl ester 
• 66760-19-8 4-(2'-hydroxyethyl)-1,2,4-triazole 
• 72796-76-0 3-(Phenyl-[1,2,4]triazol-1-yl-methyl)-pentane-2,4-dione 
• 10570-40-8 4-methyl-4H-[1,2,4]triazole 
• 1616093-49-2 C₅₂H₅₇N₈O₁₀P 
• 1616093-49-2 C₅₂H₅₇N₈O₁₀P 
• 63935-98-8 1-allyl-[1,2,4]triazole 
• 99091-96-0 4-allyl-1,2,4-triazole 

Relevant articles and documents

Heterocyclization of 3-(R-amino)-3-methylthio-1-phenylpropenones and 5-benzoyl-6-methylthio-1,2-dihydropyridin-2-ones with 1,2- and 1,3-dinucleophilic reagents

The interaction of 3-(R-amino)-3-methylthio-1-phenylpropenones and 1-alkyl-5-benzoyl-3-ethoxy-carbonyl-6-methylthio-1,2-dihydropyridin-2-ones with N,N- and N,C-1,2- and 1,3-dinucleophiles proceeded regioselectively by [3+2] and [3+3] cyclocondensation with the formation of derivatives of pyrazole, benzimidazo[1,2-a]-pyridine, benzimidazo[1,2-a]pyrimidine, imidazo[1,2-a] pyrimidine, [1,2,4]triazolo[4,3-b]pyridazine, and 6,7-dihydro-2H-pyrazolo[3,4-b] pyridine. The regioselectivity of the reactions carried out was analyzed.

Oxazole PPAR antagonist

A method is disclosed for rational design of a PPAR, FXR, LXR-alpha, or LXR-beta antagonist comprising chemical modification of a PPAR, FXR, LXR-alpha, or LXR-beta agonist to: a) prevent formation of a hydrogen bond between the agonist and tyrosine or histidine, or tryptophan involved in receptor activation; and/or b) displace the tyrosine or histidine, or tryptophan involved in receptor activation from its agonist bound position. Preferably, little or no additional changes are made in the structure of the agonist so that the resulting antagonist is a close structural analogue of the agonist. Specific examples of PPAR gamma antagonists designed and prepared using the method of this invention are compounds of Formula (I) or (II), or pharmaceutically acceptable salts or solvates thereof, where in Formula (I) X is O, S, or NH; and R is methyl, ethyl, n-propyl, i-propyl, cyclopropyl, n-butyl, phenyl, or —CH2OCH3and wherein in Formula (II) X is C or N; and R is methyl, ethyl, n-propyl, i-propyl, —CH2OCH3, or —CO2CH3.

Heteroaryl- phenyl heterobicyclic factor Xa inhibitors

The present application describes heteroaryl-phenyl heterobicycles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.