636-21-5 Usage
Description
O-TOLUIDINE HYDROCHLORIDE is a white crystalline solid that exists as green crystals or a white crystalline solid with a melting point of 215-217°F. It is highly toxic and is primarily used as an intermediate in the production of various chemicals and products.
Uses
Used in Dye and Pigment Industry:
O-TOLUIDINE HYDROCHLORIDE is used as an intermediate for the manufacture of more than 90 dyes and pigments. It is particularly utilized in the production of acid-fast dyestuffs, azo pigments and dyes, triarylmethane dyes, sulfur dyes, and indigo compounds.
Used in Photographic Industry:
O-TOLUIDINE HYDROCHLORIDE is used as a photographic dye, contributing to the development and enhancement of photographic processes.
Used in Rubber Industry:
It serves as an intermediate for synthetic rubber and rubber vulcanizing chemicals, playing a crucial role in the production and improvement of rubber materials.
Used in Pharmaceutical Industry:
O-TOLUIDINE HYDROCHLORIDE is used as an intermediate in the synthesis of various pharmaceuticals, aiding in the development of new medications and treatments.
Used in Pesticide Industry:
It is employed as an intermediate in the production of pesticides, contributing to the development of effective pest control solutions.
Used in Epoxy Resin Systems:
O-TOLUIDINE HYDROCHLORIDE acts as a curing agent in epoxy resin systems, enhancing the properties and performance of the final product.
Used in Organic Synthesis:
It is utilized as an intermediate in organic synthesis, playing a vital role in the creation of various organic compounds.
Used in Clinical Laboratory Reagents:
O-TOLUIDINE HYDROCHLORIDE is an ingredient in clinical laboratory reagents for glucose and hemoglobin analyses, aiding in the accurate measurement and diagnosis of these essential biomarkers.
Used in Hair Dye Industry:
Although O-TOLUIDINE HYDROCHLORIDE is a carcinogenic and toxic aromatic amine, it is contained in hair dye, henna, and dyed hair samples, contributing to the coloration and appearance of these products. However, its use in this industry should be carefully regulated due to its toxic nature.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
O-TOLUIDINE HYDROCHLORIDE acts as a weak acid. Incompatible with oxidizing agents and with alkalis .
Fire Hazard
Flash point data for O-TOLUIDINE HYDROCHLORIDE are not available; however, O-TOLUIDINE HYDROCHLORIDE is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic data. Poison
by intraperitoneal route. Moderately toxic by
ingestion. Mutation data reported. When
heated to decomposition it emits very toxic
fumes of HCl and NOx. See also o-
TOLUIDINE.
Carcinogenicity
o-Toluidine and o-toluidine hydrochloride are reasonably anticipatedto be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.
Check Digit Verification of cas no
The CAS Registry Mumber 636-21-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 636-21:
(5*6)+(4*3)+(3*6)+(2*2)+(1*1)=65
65 % 10 = 5
So 636-21-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H9N.ClH/c1-6-4-2-3-5-7(6)8;/h2-5H,8H2,1H3;1H
636-21-5Relevant articles and documents
Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides
Gudun, Kristina A.,Hayrapetyan, Davit,Khalimon, Andrey Y.,Segizbayev, Medet,Slamova, Ainur,Zakarina, Raikhan
, (2021/11/30)
The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.
The ortho effect on the acidic and alkaline hydrolysis of substituted formanilides
Desai, Salil Dileep,Kirsch, Lee E.
, p. 471 - 488 (2015/06/30)
The kinetics of formanilides hydrolysis were determined under first-order conditions in hydrochloric acid (0.01-8 M, 20-60°C) and in hydroxide solutions (0.01-3 M, 25 and 40°C). Under acidic conditions, second-order specific acid catalytic constants were used to construct Hammett plots. The ortho effect was analyzed using the Fujita-Nishioka method. In alkaline solutions, hydrolysis displayed both first- and second-order dependence in the hydroxide concentration. The specific base catalytic constants were used to construct Hammett plots. Ortho effects were evaluated for the first-order dependence on the hydroxide concentration. Formanilide hydrolyzes in acidic solutions by specific acid catalysis, and the kinetic study results were consistent with the AAC2 mechanism. Ortho substitution led to a decrease in the rates of reaction due to steric inhibition of resonance, retardation due to steric bulk, and through space interactions. The primary hydrolytic pathway in alkaline solutions was consistent with a modified BAC2 mechanism. The Hammett plots for hydrolysis of meta- and para-substituted formanilides in 0.10 M sodium hydroxide solutions did not show substituent effects; however, ortho substitution led to a decrease in rate constants proportional to the steric bulk of the substituent.
Hydrogenation of aromatic nitro compounds with an inexpensive and efficient CuSO4/CoCl2 catalyst prepared in situ using NaBH 4 as the hydrogen source
Ficker, Mario,Petersen, Johannes F.,Hansen, Jon S.,Christensen, Jorn B.
, p. 176 - 182 (2014/04/17)
-