636-79-3

Basic information

• Product Name: NICOTINIC ACID HYDROCHLORIDE
• Synonyms: NICOTINIC ACID HYDROCHLORIDE;Pyridine-3-carboxylic acid hydrochloride
• CAS NO: 636-79-3
• Molecular Formula: C₆H₆NO₂*Cl
• Molecular Weight: 159.57
• Mol File: 636-79-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 250-255 °C
• Boiling Point: 292.5 °C at 760 mmHg
• Flash Point: 130.7 °C
• Appearance: /
• Vapor Pressure: 0.000836mmHg at 25°C
• CAS DataBase Reference: NICOTINIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NICOTINIC ACID HYDROCHLORIDE(636-79-3)
• EPA Substance Registry System: NICOTINIC ACID HYDROCHLORIDE(636-79-3)

Safety Data

• Hazardous Substances Data: 636-79-3(Hazardous Substances Data)

Usage

Description

Nicotinic acid hydrochloride, also known as niacin or vitamin B3, is a water-soluble essential nutrient that plays a crucial role in energy metabolism and the maintenance of a healthy nervous system. It is an important component of coenzymes involved in cellular respiration and the production of ATP.

Uses

Used in Pharmaceutical Industry:
Nicotinic acid hydrochloride is used as a treatment for niacin deficiency, helping to alleviate symptoms and restore proper nutrient levels in the body.
Used in Cardiovascular Health:
Nicotinic acid hydrochloride is used as a management tool for conditions such as high cholesterol and triglyceride levels, potentially reducing the risk of cardiovascular disease.
Used in Nutritional Supplements:
Nicotinic acid hydrochloride is used as a nutritional supplement to help improve circulation and cognitive function, supporting overall health and well-being.

InChI:InChI=1/C6H5NO2.ClH/c8-6(9)5-2-1-3-7-4-5;/h1-4H,(H,8,9);1H

Upstream product

• 59-67-6 nicotinic acid 
• 81469-77-4 methyl 3,4,5-trimethoxy-2-((2-((3-pyridinylcarbonyl)amino)benzoyl)amino)benzoate 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 5324-30-1 diethyl 2-bromoethylphosphonate 
• 500-22-1 3-pyridinecarboxaldehyde 

Downstream Products

• 212503-75-8 N-nicotinoyl-2-methyl-6-nitroanilide 
• 498-95-3 nipecotic acid 
• 199594-74-6 1-(2,6-difluorobenzyl)-2-(3-pyridinyl)-4-methylbenzimidazole 
• 87951-26-6 1-Amino-3-(2-trimethylsilylethoxycarbonyl)pyridinium-mesitylensulfonat 
• 15268-31-2 3-Pyridyl isocyanate 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 

Relevant articles and documents

Multitechnique experimental insight on an unusual crystal-to-crystal high temperature solid state reaction in zirconium carboxypyridinephosphonates: From one-dimensional chains to two-dimensional hybrid layers through HF elimination

Two novel N-phosphonoethylcarboxypyridines were prepared via nucleophilic substitution of two carboxypyridines (namely, 4-carboxypyridine, or isonicotinic acid, and 3-carboxypyridine, or nicotinic acid) with diethyl-2- bromoethylphosphonate in water. Two zirconium derivatives of these acids were obtained under mild solvothermal conditions, and their structures were solved from powder X-ray diffraction (PXRD) data. The zirconium derivative containing the isonicotinic moiety (1), with formula ZrF2(HF)(O 3PCH2CH2NC5H4CO 2), has a one-dimensional (1D) chain structure in which the carboxypyridine groups are placed in the external part of the inorganic chain constituted of zirconium octahedra and phosphonic tetrahedra, whereas the zirconium derivative containing the nicotinic moiety (2), with formula ZrF 2(O3PCH2CH2NC5H 4CO2), has a hybrid layered structure in which zirconium octhaedra and phosphorus tetrahedra form a new structural archetype, with a C-O group coordinating the zirconium atoms. 1 underwent a high temperature (280 °C) slow solid state transformation that involved the loss of one HF molecule coordinated to the zirconium atom and the replacement of this coordination vacancy with the neighboring C-O- group belonging to the adjacent chain. The structure of this heated compound (1a) is a polymorph of 2. A multitechnique approach, based on coupled Fourier transform infrared spectroscopy and Raman and solid state NMR spectroscopy allowed us to carry out a thorough characterization of these materials, finding nice agreements on the chemical details of this solid state reaction.

On the Synthesis of 8-Amino-5-aza-1,3-nonamdiene Derivatives

Starting from glycine derivatives and the diazepines 1, 8-succinimido-5-aza-1,3-nonamdienes 5 and 8-phthalimido-5-aza-1,3-nonamdienes 8 are synthesized stereospecifically in trans configuration.Cleavage of the side-chain leads in particular to the unstabl