6362-63-6Relevant articles and documents
Maleic anhydride derivatives used as conjugation agents of anti-tumor agents on desired carriers
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, (2008/06/13)
The present invention relates to anti-tumor-conjugation agent-protein compounds of the general formula I: STR1 wherein, R1 and R2 are each independently selected from hydrogen atom, C1-4 alkyl, C1-4 alkoxy, C1-6 carboxyalkyl, phenyl, or phenyl substituted by at least one of hydroxy, halogen, lower alkyl, lower alkoxy, or nitro, with the proviso that R1 and R2 cannot be simultaneously a hydrogen, and when one of R1 or R2 is a hydrogen, the other one cannot be --CH2 COOH; A is the residue of an anti-tumor agent containing at least one amino group available to form an amide bound; and B is a free ε-lysine containing residue selected from a peptide or a protein.
Regioselectivity control in metal hydride reductions of substituted maleic anhydrides
Kayser, Margaret M.,Breau, Livain,Eliev, Sonia,Morand, Peter,Ip, H. S.
, p. 104 - 109 (2007/10/02)
A systematic study of reductions of unsymmetrically substituted maleic anhydrides by a variety of metal hydride reagents indicates that the high regioselectivity observed in these reactions is controlled chiefly by electronic factors.
Ester derivatives of pulvinic acid
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, (2008/06/13)
Pharmaceutical compositions having anti-arthritic activity comprising an ester derivative of pulvinic acid and methods of producing anti-arthritic activity by administering internally said compositions. Certain of the pulvinic acid derivatives are novel compounds per se.
