63650-24-8Relevant articles and documents
Cyclohexane-1,3-diketone compound as well as synthesis method and application thereof
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Paragraph 0032-0035; 0040-0041, (2020/06/16)
The invention provides a cyclohexane-1,3-diketone compound of which the structural formula is shown in the specification, wherein the group R1 in the structural formula I is -CH3, -CH2CH3, -(CH2)2CH3,-CH(CH3)2, -(CH2)3CH3, -CH(CH3)C2H5, -CH2CH(CH3)2 or -C
Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature
Rasu, Loorthuraja,John, Jeremy M.,Stephenson, Elanna,Endean, Riley,Kalapugama, Suneth,Clément, Roxanne,Bergens, Steven H.
, p. 3065 - 3071 (2017/03/11)
High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.
Resolution of 2-aryloxy-1-propanols via lipase-catalyzed enantioselective acylation in organic media
Miyazawa, Toshifumi,Yukawa, Tomoyuki,Koshiba, Takashi,Sakamoto, Hiroko,Ueji, Shinichi,Yanagihara, Ryoji,Yamada, Takashi
, p. 1595 - 1602 (2007/10/03)
2-Aryloxy-1-propanols, primary alcohols with an oxygen atom at the stereocenter, were resolved with good to high enantioselectivity by acylation with vinyl butanoate mediated by Pseudomonas sp. lipase in di-iso-propyl ether. Potential factors affecting the enantioselectivity of the enzymatic acylation were examined: solvents, acyl donors and temperature. Using this enantioselective acylation procedure, enantiomerically pure (R)-2-(4-chlorophenoxy)-1-propanol was prepared on a gram scale.