63658-17-3

Basic information

• Product Name: 2-Propenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-phenyl-, methyl ester, (E)-
• CAS NO: 63658-17-3
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Mol File: 63658-17-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-phenyl-, methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-phenyl-, methyl ester, (E)-(63658-17-3)
• EPA Substance Registry System: 2-Propenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-phenyl-, methyl ester, (E)-(63658-17-3)

Safety Data

• Hazardous Substances Data: 63658-17-3(Hazardous Substances Data)

Upstream product

• 136620-76-3 methyl (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-((methanesulfonyl)oxy)-3-phenylpropionate 
• 121056-95-9 trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate 
• 100-52-7 benzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1438888-28-8 C₂₈H₃₀NO₉P 
• 1438888-29-9 C₂₀H₂₄NO₇P 
• 606937-28-4 Boc-(Z)-ΔPhe(β-Br)-OMe 
• 606937-27-3 Boc-(E)-ΔPhe(β-Br)-OMe 
• 153393-01-2 methyl 2-(bis(tert-butoxycarbonyl)amino)acetate 
• 55065-02-6 2-(N-acetylamino)cinnamic acid 
• 52386-78-4 N-acetyl dehydrophenylalanine methyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 136642-82-5 methyl (4S,5R)-3-N-tert-butoxycarbonyl-5-phenyl-1,3-oxazolidin-2-oxo-4-carboxylate 
• 154409-62-8 methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate 

Downstream Products

• 103999-81-1 2-Isocyanato-3-phenylpropensaeure-methylester 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 19901-50-9 methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate 
• 1086602-45-0 Boc-Z-ΔPhe(β-I)-OMe 
• 63096-29-7 Boc-α,β-Dehydrophenylalanin 

Relevant articles and documents

Synthesis of β-silyl α-amino acids via visible-light-mediated hydrosilylation

An expedient synthesis of β-silyl α-amino acids is reported via the application of visible-light-mediated hydrosilylation. The reaction utilizes readily accessible and structurally diverse hydrosilanes to provide radicals for conjugate addition to dehydroalanine ester and analogues. Notably, the use of chiral methyleneoxazolidinone as the substrate and chiral inducer enabled the highly stereoselective synthesis. Furthermore, the reaction could also be performed in a continuous flow fashion and scaled up to the gram scale.

Elucidation of Racemization Process of Azaspirene Skeleton in Neutral Aqueous Media

Azaspirene and related congeners, which possess various biological activities, have a unique spirocyclic core structure. However, there are few studies on the chemical properties of (-)-azaspirene, despite the fact that it may provide important insights into unveiling the biosynthetic pathway. Here, we report a nine-step chemical synthesis of an azaspirene analogue with a new finding that the natural (-)-azaspirene skeleton easily racemizes in neutral aqueous media.

CHIRAL FLUORINATING REAGENTS

This invention relates to fluorinating agents and, more particularly, to chiral non-racemic fluorinating agents useful for enantioselective fluorination, as well as to their synthesis and use and other subject matter. The fluorinating agents are based on a substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) skeleton and provide electrophillic fluorine enantioselectively.