63659-16-5

Basic information

• Product Name: 4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL
• Synonyms: 4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL;Betaxolol IMp. D (EP);Phenol, 4-[2-(cyclopropylMethoxy)ethyl]-
• CAS NO: 63659-16-5
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• EINECS: 917-869-5
• Product Categories: Aromatics Compounds;Aromatics;Intermediates
• Mol File: 63659-16-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 304.439 °C at 760 mmHg
• Flash Point: 129.347 °C
• Appearance: Colourless oil
• Density: 1.112 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 10.01±0.15(Predicted)
• CAS DataBase Reference: 4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL(63659-16-5)
• EPA Substance Registry System: 4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL(63659-16-5)

Safety Data

• Hazardous Substances Data: 63659-16-5(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

Different sources of media describe the Uses of 63659-16-5 differently. You can refer to the following data:
1. An intermediate for the synthesis of Betaxolol
2. 4-[2-(Cyclopropylmethoxy)ethyl]phenol (Betaxolol EP Impurity D) is an intermediate for the synthesis of Betaxolol.

InChI:InChI=1/C12H16O2/c13-12-5-3-10(4-6-12)7-8-14-9-11-1-2-11/h3-6,11,13H,1-2,7-9H2

Upstream product

• 63659-15-4 1-benzyloxy-4-(2-cyclopropylmethoxyethyl)benzene 
• 890704-23-1 para-[2-(cyclopropylmethoxy)ethyl] aniline 
• 890704-21-9 cyclopropylmethyl vinyl ether 
• 890704-22-0 1-(2-cyclopropylmethoxyethenyl)-4-nitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 761449-63-2 1-(2-alyloxyethyl)-4-benzyloxybenzene 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 61439-59-6 2-(4-benzyloxyphenyl)ethanol 
• 56441-69-1 2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester 

Downstream Products

• 104857-50-3 (5S)-5-(4-((2-cyclopropylmethoxy)ethyl)phenoxy)methyl-3-isopropyl-2-phenyloxazolidine 
• 108587-94-6 (2S)-N-benzyl-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-2-hydroxypropylamine 
• 63659-17-6 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene 
• 108008-05-5 (R)-(+)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1,2-propanodiol acetonide 
• 128645-29-4 1-allyloxy-4-(2-cyclopropylmethoxyethyl)benzene 
• 93221-48-8 (-)-Betaxolol 
• 111794-56-0 6-<4-<3-phenoxy>-2-hydroxypropyl>amino>propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 101328-88-5 (2S)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-2-hydroxypropylamine 
• 101328-82-9 6-[4-[3-[2-hydroxy-3-[4-(2-(cyclopropylmethoxy) ethyl)phenoxy]propylamino]propionamido]phenyl]-5-methyl-4,5-dihydro-3 (2H)-pyridazinone 
• 63659-18-7 betaxolol 

Relevant articles and documents

PROCESS FOR PREPARATION OF PHENOXYPROPANOL AMINES

The present invention describes an improved method for the preparation of l-[4-{2- (cyclopropylmethoxy)ethyl}phenoxy]-3-[(1-methylethyl)amino]-2-propanol of Formula-(I) and its pharmaceutically acceptable salt, which comprises reacting 4 - [ 2 — (Cyclopropylmethoxy) ethyl] phenol with epichlorohydrin in presence of mild base and polar protic solvent to isolate 1 - {4 - [2 - (cyclopropylmethoxy)ethyl] - phenoxy} - 2, 3 - epoxy propane, which is further reacted with isopropyl amine to get betaxolol formula (I).

PROCESS FOR PREPARATION OF S-(-)-BETAXOLOL AND SALTS THEREOF

The present invention relates to an improved process for preparation of S-(?)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(?)-betaxolol of formula (1).

Synthesis of a series of compounds related to betaxolol, a new β1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases

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