63671-68-1

Basic information

• Product Name: 2-{[(pyridin-2-ylmethyl)amino]methyl}phenol
• Synonyms: 2-{[(pyridin-2-ylmethyl)amino]methyl}phenol
• CAS NO: 63671-68-1
• Molecular Formula: C₁₃H₁₄N₂O
• Molecular Weight: 214.26306
• Mol File: 63671-68-1.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-{[(pyridin-2-ylmethyl)amino]methyl}phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(pyridin-2-ylmethyl)amino]methyl}phenol(63671-68-1)
• EPA Substance Registry System: 2-{[(pyridin-2-ylmethyl)amino]methyl}phenol(63671-68-1)

Safety Data

• Hazardous Substances Data: 63671-68-1(Hazardous Substances Data)

Usage

Derivative of phenol

Contains a pyridylmethylamino group attached to the phenol ring

Potential biological activities

Anti-tumor agent, ability to inhibit the proliferation of cancer cells

Potential use in

Fluorescence imaging, coordination chemistry as a ligand

Versatile molecule

Applicable in various fields of research and technology

Upstream product

• 137129-33-0 2-((pyridin-2-ylmethylimino)methyl)phenol 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 90-02-8 salicylaldehyde 
• 1121-60-4 pyridine-2-carbaldehyde 
• 932-30-9 2-Hydroxybenzylamine 
• 137129-33-0 2-((E)-((pyridin-2-yl)methylimino)methyl)phenol 

Downstream Products

• 170659-81-1 2-[[bis(2-pyridinomethyl)amino]methyl]-6-[[[(2-hydroxyphenyl)methyl](2-pyridinylmethyl)amino]methyl]-4-methylphenol 
• 205313-75-3 2-(((2-hydroxybenzyl)(pyridin-2-ylmethyl)amino)methyl)-4-nitrophenol 
• 123674-05-5 N,N-bis(2-hydroxybenzyl)-N-(2-pyridylmethyl)amine 
• 630393-55-4 2-(4-hydroxy-3,5-bis{[(2-hydroxybenzyl)pyridin-2-ylmethylamino]methyl}benzyl)isoindole-1,3-dione 
• 156976-59-9 {Zn(C₆H₄(OH)CH₂NHCH₂C₅H₄N)I₂} 
• 153114-19-3 2,6-[N,N'-bis(2-hydroxyphenylmethyl)-N,N'-bis(2-pyridylmethyl)aminomethyl]-4-methylphenol 
• 1350802-70-8 1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol 
• 1401696-16-9 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(benzyl)amino]propan-2-ol 
• 1401696-19-2 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4-methylbenzyl)amino]propan-2-ol 
• 1415903-47-7 C₂₂H₁₇N₃O₅ 
• 760147-40-8 [Zinc(II)(2-hydroxybenzyl-(2-pyridylmethyl)amine)Cl₂] 

Relevant articles and documents

Synthesis, characterization and DFT studies of a new unsymmetrical dinuclear Vanadium(IV) complex with a bipodal N2O-donor ligand

A new dinuclear vanadium(IV) complex [(VO)2(μ-HBPA)2(μ-SO4)].4.75H2O was synthesized by the reaction between a bipodal N2O-donor ligand N-(2-hydroxybenzyl)-N-(pyridin-2-ylmethyl)amine (HBPA) and vanad

Turn-on selective fluorescent probe for trivalent cations

A novel fluorescent sensor 1 (1 = 10-(2-(((pyridin-2-yl)methylamino)methyl) phenol)methyl-anthracene) for trivalent cations has been synthesized and characterized. Both UV-vis and fluorescence spectroscopic studies demonstrated that the new receptor 1 was

Copper(II) Pyridyl Aminophenolates: Hypoxia-Selective, Nucleus-Targeting Cytotoxins, and Magnetic Resonance Probes

Targeting the low-oxygen (hypoxic) environments found in many tumours by using redox-active metal complexes is a strategy that can enhance efficacy and reduce the side effects of chemotherapies. We have developed a series of CuII complexes with

Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage

Ascorbate is an important biological reductant and enzyme cofactor. Although direct detection through ascorbate-mediated reduction is possible, this approach suffers from poor selectivity due to the wide range of cellular reducing agents. To overcome this limitation, we leverage reduction potential of ascorbate to mediate a copper-mediated oxidative bond cleavage of ether-caged fluorophores. The copper(II) complexes supported by a {bis(2-pyridylmethyl)}benzylamine or a {bis(2-pyridylmethyl)}(2-methoxybenzyl)amine ligand were identified as an ascorbate responsive unit and their reaction with ascorbate yields a copper-based oxidant that enables rapid benzylic oxidation and the release of an ether-caged dye (coumarin or fluorescein). The copper-mediated bond cleavage is specific to ascorbate and the trigger can be readily derivatized for tuning photophysical properties of the probes. The probes were successfully applied for the fluorometric detection of ascorbate in commercial food samples, human plasma, and serum, and within live cells by using confocal microscopy and flow cytometry.