637029-17-5

Basic information

• Product Name: (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten
• Synonyms: (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten
• CAS NO: 637029-17-5
• Molecular Weight: 655.049
• Mol File: 637029-17-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten(CAS DataBase Reference)
• NIST Chemistry Reference: (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten(637029-17-5)
• EPA Substance Registry System: (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten(637029-17-5)

Safety Data

• Hazardous Substances Data: 637029-17-5(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 324740-29-6 3-O-(tert-butyldiphenylsilyl)diosgenin 

Downstream Products

• 14320-81-1 20-epi-verazine 
• 637029-28-8 (22R,25R)-3β-(2,4-di-O-benzoyl-3,6-di-O-tert-butyldimethylsilyl-β-D-glucopyranosyloxy)-26-p-methoxybenzyloxy-5-furosten 
• 637029-29-9 C₅₃H₉₀O₉Si₂ 
• 637029-19-7 (22R,25R)-3β-hydroxy-26-p-methoxybenzyloxy-5-furosten 
• 637029-18-6 (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-p-methoxybenzyloxy-5-furosten 

Relevant articles and documents

Stereoselective Synthesis of (-)-Verazine and Congeners via a Cascade Ring-Switching Process of Furostan-26-acid

An efficient synthetic strategy for three natural seco-type cholestane alkaloids isolated from the Veratrum plants, based on commercially available naturally occurring and abundant (-)-diosgenin (1), as exemplified in the concise asymmetric synthesis of (-)-verazine (4), (-)-veramiline (5) (proposed structure), and its 22-epimer, (-)-oblonginine (6), is presented. This work highlights the application of a cascade ring-switching process of (-)-diosgenin to achieve the E-ring opening and construction of chiral six-membered lactone challenges in seco-type cholestane alkaloid synthesis. This approach enables the synthesis of related natural and nature-like novel cholestane alkaloids, opening up opportunities for more extensive exploration of cholestane alkaloid biology.