63715-95-7

Basic information

• Product Name: Acetic acid 2-hydroxy-3-phenoxypropyl ester
• Synonyms: 1-Acetoxy-3-phenoxy-2-propanol;3-Phenoxy-1,2-propanediol=1-acetate;Acetic acid 2-hydroxy-3-phenoxypropyl ester
• CAS NO: 63715-95-7
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol File: 63715-95-7.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 355.6°C at 760 mmHg
• Flash Point: 137.3°C
• Appearance: /
• Density: 1.162g/cm³
• Vapor Pressure: 1.13E-05mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: Acetic acid 2-hydroxy-3-phenoxypropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 2-hydroxy-3-phenoxypropyl ester(63715-95-7)
• EPA Substance Registry System: Acetic acid 2-hydroxy-3-phenoxypropyl ester(63715-95-7)

Safety Data

• Hazardous Substances Data: 63715-95-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14O4/c1-9(12)14-7-10(13)8-15-11-5-3-2-4-6-11/h2-6,10,13H,7-8H2,1H3

Upstream product

• 4769-73-7 (RS)-1-chloro-3-phenyloxy-2-propanol 
• 538-43-2 3-phenoxy-1,2-propanediol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 24573-30-6 3-chloro-2-hydroxy-1-propyl acetate 
• 139-02-6 sodium phenoxide 
• 108-05-4 vinyl acetate 
• 122-60-1 Phenyl glycidyl ether 
• 64-19-7 acetic acid 
• 127-09-3 sodium acetate 
• 604-69-3 β-D-glucose pentaacetate 
• 108-95-2 phenol 
• 2466-76-4 N-Acetylimidazole 

Downstream Products

• 204584-17-8 1-acetoxy-3-phenoxy-acetone 
• 93647-11-1 2-Methoxy-1-acetoxy-3-phenoxy-propan 
• 538-43-2 (S)-3-phenoxy-1,2-propanediol 
• 82430-38-4 (S)-1-phenyl glycerol 
• 147220-19-7 (R)-1-acetoxy-3-phenoxypropan-2-ol 
• 204584-30-5 (S)-1-acetoxy-3-phenoxypropan-2-ol 
• 296269-89-1 1-hydroxy-3-phenoxy-2-propanone 
• 7250-71-7 1,2-di-O-acetyl-3-(phenoxy)propane-1,2-diol 

Relevant articles and documents

Diol-Ritter Reaction: Regio- And Stereoselective Synthesis of Protected Vicinal Aminoalcohols and Mechanistic Aspects of Diol Monoester Disproportionation

The well-known epoxide-Ritter reaction generally affords oxazolines with poor to average regioselectivity. Herein, a mechanism-based study of the less known diol-Ritter reaction has provided a highly regioselective procedure for the synthesis of 1-vic-amido-2-esters from either terminal epoxides or 1,2-diols via Lewis acid-catalyzed monoesterification. When treated with a stoichiometric Lewis acid catalyst (BF3), these diol monoesters form dioxonium cation intermediates that are ring-opened with nitrile nucleophiles to form nitrilium intermediates, which undergo rapid and irreversible hydration to give the desired amidoesters. Diester byproduct formation is irreversible and appears to occur through disproportionation of diol monoester. With chiral epoxide starting materials, the formation of amidoester occurs with retention of configuration and no apparent erosion of optical purity as determined by single-crystal X-ray analyses and chiral chromatography, respectively. The direct access to chiral vic-amidoesters is especially practical with regard to the synthesis of antibacterial oxazolidinone analogues of the Zyvox antimicrobial family.

A highly efficient protocol for regioselective ring-opening of epoxides with alcohols, water, acetic acid, and acetic anhydride catalyzed by SbF3

SbF3as an efficient catalyst has been used for regioselective alcoholysis, acetolysis and hydrolysis of epoxides to the corresponding β-alkoxy, β-acetoxy alcohols, and 1,2-diols in high to excellent yields. This study also represents a convenient synthesis of vic-diacetates from ring-opening of epoxides with acetic anhydride.

Synthesis and characterization of a novel Fe3O4@SiO2/bipyridinium dichloride nanocomposite and its application as a magnetic and recyclable phase-transfer catalyst in the preparation of β-azidoalcohols, β-cyanohydrins, and

β-Azidoalcohols, β-cyanohydrins, and β-acetoxy alcohols have been synthesized in the presence of a Fe3O4@SiO2/bipyridinium nanocomposite (Fe3O4@SiO2/BNC) as a novel magnetic and recyclable