63788-62-5

Basic information

• Product Name: 2-Acetylamino-4-methyl-thiazole-5-carboxylic acid
• Synonyms: 2-Acetylamino-4-methyl-thiazole-5-carboxylic acid;5-Thiazolecarboxylic acid, 2-(acetylamino)-4-methyl-;2-acetaMido-4-Methyl-1,3-thiazole-5-carboxylic acid;2-ACETAMIDO-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID
• CAS NO: 63788-62-5
• Molecular Formula: C₇H₈N₂O₃S
• Molecular Weight: 200
• Mol File: 63788-62-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Acetylamino-4-methyl-thiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetylamino-4-methyl-thiazole-5-carboxylic acid(63788-62-5)
• EPA Substance Registry System: 2-Acetylamino-4-methyl-thiazole-5-carboxylic acid(63788-62-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 63788-62-5(Hazardous Substances Data)

Usage

General Description

2-Acetylamino-4-methyl-thiazole-5-carboxylic acid is a chemical compound with pharmaceutical potential due to its ability to inhibit the production of bacterial biofilms, making it a promising candidate for the development of new antibiotics. It is also known for its anti-cancer properties and has been studied for its potential use in cancer treatment. Additionally, this compound has shown potential as an anti-inflammatory agent, making it a versatile and valuable chemical in the field of medicine and drug development.

Upstream product

• 63788-59-0 2-amino-4-methylthiazole-5-carboxylic acid hydrazide 
• 108-24-7 acetic anhydride 
• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 67899-00-7 2-amino-4-methyl-thiazole-5-carboxylic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 7336-51-8 2-acetamido-4-methylthiazole 
• 1446020-07-0 C₂₈H₃₂N₄O₃S 
• 1292300-75-4 N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide 
• 1594128-61-6 2-acetamido-N-((S)-1-(4-((R)-1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl-4-methyl)thiazole-5-carboxamide 
• 1620686-60-3 2-acetamido-N-((1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethyl)-4-methylthiazole-5-carboxamide 
• 1620687-93-5 C₂₈H₃₁F₂N₅O₄S 

Relevant articles and documents

Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4- methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases

Class I phosphoinositide 3-kinases (PI3Ks), particularly PI3Kγ, have become attractive drug targets for inflammatory and autoimmune disorders such as rheumatoid arthritis. Herein, we describe the synthesis and the structure-activity relationships (SAR) of a series of 2-amino-5-oxadiazolyl thiazoles, culminating in the identification of 8j (TASP0415914), an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TASP0415914 demonstrated good potency in a cell-based assay and, furthermore, exhibited in vivo efficacy in a collagen induced arthritis (CIA) model in mice after oral administration.