63796-41-8

Basic information

• Product Name: (1R,4aS,10aR)-N-benzyl-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide
• CAS NO: 63796-41-8
• Molecular Weight: 389.581
• Mol File: 63796-41-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,4aS,10aR)-N-benzyl-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4aS,10aR)-N-benzyl-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide(63796-41-8)
• EPA Substance Registry System: (1R,4aS,10aR)-N-benzyl-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide(63796-41-8)

Safety Data

• Hazardous Substances Data: 63796-41-8(Hazardous Substances Data)

Upstream product

• 471-77-2 neoabietic acid 
• 514-10-3 abietic acid 
• 22478-66-6 dehydroabietic acid chloride 
• 100-46-9 benzylamine 
• 1740-19-8 dehydroabietic acid 

Relevant articles and documents

Site-Selective Electrochemical Benzylic C?H Amination

C?H/N-H cross-coupling is an ideal strategy to synthesize various amines but remains challenging owing to the requirement for sacrificial chemical oxidants and the difficulty in controlling the regio- and chemo-selectivity. Herein we report a site-selective electrochemical amination reaction that can convert benzylic C?H bonds into C-N linkages via H2 evolution without need for external oxidants or metal catalysts. The synthetic strategy involves anodic cleavage of benzylic C?H to form a carbocation intermediate, which is then trapped with an amine nucleophile leading to C?N bond formation. Key to the success is to include HFIP as a co-solvent to modulate the oxidation potentials of the alkylbenzene substrate and the aminated product to avoid overoxidation of the latter.