638-43-7 Usage
Description
[(2-aminoethyl)disulfanyl]acetic acid, also known as tiopronin, is a pharmaceutical compound derived from the amino acid cysteine. It possesses thiol properties and exhibits antioxidant characteristics, making it a versatile chemical with significant medical applications.
Uses
Used in Pharmaceutical Applications:
[(2-aminoethyl)disulfanyl]acetic acid is used as a therapeutic agent for the treatment of kidney stones and cystinuria, a genetic disorder that leads to the formation of cystine stones in the kidneys and bladder. It functions by binding to cystine molecules, preventing their aggregation and subsequent stone formation.
Used in Heavy Metal Detoxification:
Tiopronin is also utilized as a detoxifying agent for heavy metal poisoning or toxicity. It enhances the excretion of heavy metals, such as mercury and lead, from the body, providing a crucial treatment option in cases of heavy metal exposure.
Used in Antioxidant Therapy:
Due to its antioxidant properties, [(2-aminoethyl)disulfanyl]acetic acid can be employed in antioxidant therapy to counteract oxidative stress and protect cells from damage caused by reactive oxygen species.
Check Digit Verification of cas no
The CAS Registry Mumber 638-43-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 8 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 638-43:
(5*6)+(4*3)+(3*8)+(2*4)+(1*3)=77
77 % 10 = 7
So 638-43-7 is a valid CAS Registry Number.
638-43-7Relevant articles and documents
A kinetic approach to characterize the electrostatic environments of thiol groups in proteins
Zhang, Hao,Le, Min,Means, Gary E.
, p. 356 - 364 (2007/10/03)
In this study, we synthesized a zwitterionic DTNB derivative, 5-(2- aminoethyl)-dithio-2-nitrobenzoate (ADNB), and characterized its reactions with several cationic, anionic, and neutral thiols. Reactions with ADNB, unlike those with DTNB, are relatively insensitive to electrostatic environments and ionic strengths. At relatively low ionic strength, rate ratios, k(ADNB)/k(DTNB), varied from 0.22 for reactions with low-molecular- weight cationic thiols to 3.0 for those with low-molecular-weight anionic thiols. A k(ADNB)/k(DTNB) ratio of ~200 for Cys-34 of BSA appears to reflect a very anionic environment. k(ADNB)/k(DTNB) ratios of ~6 and ~1, respectively, for canine and equine serum albumins, which have Glu-82 → Asp and Glu-82 → Ala substitutions suggest Glu-82 is the most important anionic residues affecting the reactivity of Cys-34 in BSA. k(ADNB)/k(DTNB) ratios appear to be useful for characterizing electrostatic environments of thiol groups in proteins.
