638-96-0Relevant articles and documents
New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells
Bini Araba, Asma,Ur Rehman, Najeeb,Al-Araimi, Amna,Al-Hashmi, Sulaiman,Al-Shidhani, Sulaiman,Csuk, Rene,Hussain, Hidayat,Al-Harrasi, Ahmed,Zadjali, Fahad
, p. 707 - 716 (2021)
A series of new 11-keto-β-boswellic acid were partially-synthesized by modifying the hydroxyl and carboxylic acid functional groups of ring A. The structures of the new analogs were confirmed by detailed spectral data analysis. Compounds 4, 5 and 9 exhibi
UPLC-ESI-QTOF-MS2 characterisation of Cola nitida resin fractions with inhibitory effects on NO and TNF-α released by LPS-activated J774 macrophage and on Trypanosoma cruzi and Leishmania amazonensis
Frankenberger, Larissa,D. Mora, Tamara,de Siqueira, Carolina D.,Filippin-Monteiro, Fabiola B.,de Moraes, Milene H.,Biavatti, Maique W.,Steindel, Mario,Sandjo, Louis P.
, p. 577 - 589 (2018/06/04)
Introduction: The resin of Cola nitida is used in western Cameroon as incense for spiritual protection and during ritual ceremonies. This plant secretion has never been investigated although previous chemical and biological studies on other resins have drawn many attentions. Objective: The resin fractions which revealed inhibitory effect on nitric oxide (NO) and tumour necrosis factor alpha (TNF-α) released by lipopolysaccharide (LPS)-activated J774 macrophage as well as on intracellular forms of Leishmania amazonensis and Trypanosoma cruzi amastigote were chemically characterised. Moreover, their antiparasitic activities were compared to those of semi-synthetic triterpenes. Methodology: The anti-inflammatory activity was evaluated by measuring the nitrite production and the TNF-α concentration in the supernatants of LPS-activated macrophages by antigen capture enzyme-linked immunosorbent assay. Moreover, the antiparasitic assay was performed by infecting the host cells (THP-1) in a ratio parasite/cell 10:1 (L. amazonensis) and 2:1 (T. cruzi) and then exposed to the samples. The resin was separated in vacuo by liquid chromatography because of its sticky behaviour and the chemical profiles of the obtained fractions (F1–F4) were established by dereplication based on UPLC-ESI-MS2 data while semi-synthetic triterpenes were prepared from α-amyrin by oxidation reactions. Results: Fractions F1–F4 inhibited NO and TNF-α almost similarly. However, only F1, F3 and F4 showed promising antiparasitic activities while F2 was moderately active against both parasites. Hence, F1–F4 were exclusively composed of pentacyclic triterpenes bearing oleanane and ursane skeletons. Semi-synthetic compounds revealed no to moderate antiparasitic activity compared to the fractions. Conclusion: Although it will be difficult to prove the interaction resin-spirit, interesting bioactivities were found in the resin fractions.
Synthesis of α-amyrin derivatives and their in vivo antihyperglycemic activity
Narender,Khaliq,Singh,Joshi,Mishra,Chaturvedi,Srivastava,Maurya,Agarwal
experimental part, p. 1215 - 1222 (2009/09/30)
Ficus racemosa belongs to the family of Moraceae and is commonly known as 'Gular' in north India. Bio-activity guided isolation work on the fruits of F. racemosa resulted in the identification of antidiabetic active principle, α-amyrin acetate 7. Compound 7 lowered the blood glucose levels by 18.4 and 17.0% at 5 and 24 h, respectively, in sucrose challenged streptozotocin induced diabetic rat (STZ-S) model at the dose of 100 mg/kg body weight. Fifteen novel derivatives viz, 9-21, 24, 25 of α-amyrin 8 were prepared and their antihyperglycemic activity profile was assessed. The p-chlorobenzoic acid derivative 9 and nicotinic acid derivative 14 showed potent antihyperglycemic activity at 100 mg/kg body weight.
