63833-47-6Relevant articles and documents
Synthesis of Three New Tricyclic Ring Systems: Pyrrolotriazepines Condensed with an Imidazole, a Triazole, or a Tetrazole Ring
Milen, Mátyás,F?ldesi, Tamás,Dancsó, András,Simig, Gyula,Volk, Balázs
, p. 2418 - 2424 (2015)
In a previous paper, we have disclosed a practical synthesis of 1-aryl-3H-pyrrolo[2,1-d][1,2,5]triazepin-4(5H)-ones. Now, these compounds have been used as the starting materials for the synthesis of three new ring systems, pyrrolotriazepines condensed wi
CDy14: A novel biofilm probe targeting exopolysaccharide Psl
Kwon, Haw-Young,Kim, Jun-Young,Lee, Jung Yeol,Yam, Joey Kuok Hoong,Hultqvist, Louise Dahl,Xu, Wang,Rybtke, Morten,Tolker-Nielsen, Tim,Kim, Jong-Jin,Kang, Nam-Young,Yang, Liang,Park, Sung-Jin,Givskov, Michael,Chang, Young-Tae
supporting information, p. 11865 - 11868 (2018/12/01)
Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.
Detection of Pathogenic Biofilms with Bacterial Amyloid Targeting Fluorescent Probe, CDy11
Kim, Jun-Young,Sahu, Srikanta,Yau, Yin-Hoe,Wang, Xu,Shochat, Susana Geifman,Nielsen, Per Halkj?r,Dueholm, Morten Simonsen,Otzen, Daniel E.,Lee, Jungyeol,Delos Santos, May Margarette Salido,Yam, Joey Kuok Hoong,Kang, Nam-Young,Park, Sung-Jin,Kwon, Hawyoung,Seviour, Thomas,Yang, Liang,Givskov, Michael,Chang, Young-Tae
supporting information, p. 402 - 407 (2016/01/25)
Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic, diagnosis of biofilm-associated infections relies heavily on culturing methods, which fail to detect nonculturable bacteria. Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagnosis of pathogenic bacterial infection. Herein, we report a novel fluorescent probe, CDy11 (compound of designation yellow 11), which targets amyloid in the Pseudomonas aeruginosa biofilm matrix through a diversity oriented fluorescent library approach (DOFLA). CDy11 was further demonstrated for in vivo imaging of P. aeruginosa in implant and corneal infection mice models.