63853-82-7Relevant articles and documents
Intramolecular [4+2] cycloaddition in n-allyl- and n-propargyl-α-furyl lactams
Poplevin, Dmitry S.,Nikitina, Eugeniya V.,Zaytsev, Vladimir P.,Varlamov, Alexey V.,Tilve, Santosh G.,Zubkov, Fedor I.
, p. 451 - 457 (2018/06/11)
The size of nitrogen heterocycle in N-allyl- and N-propargyl-α-furyl lactams, as well as the nature of the unsaturated substituent linked to the nitrogen atom affected the possibility of thermal intramolecular [4+2] cycloaddition between multiple bond and the furan ring. N-Allyl-γ-(α-furyl)butyrolactam was shown to be unreactive at temperatures from 140 to 230°С. Substituted δ-valero- and ε-caprolactams underwent partial Diels–Alder cyclization, forming tautomeric mixtures that contained both the initial open-chain form and the cyclic form (diastereomeric 3a,6-epoxyisoindoles fused with an aza ring) in ratios between 19:81 and 55:45. N-Propargyl-α-furyl lactams did not participate in thermal IMDAF reaction regardless of the ring size and the temperature of the synthesis.
A New -Type Annelation Useful for the Formation of Piperidine Skeletons
Shono, Tatsuya,Matsumura, Yoshihiro,Uchida, Kenshi,Kobayashi, Hidekazu
, p. 3243 - 3245 (2007/10/02)
A -type annelation between α,α'-dimethoxylated amides 4 and allyltrimethylsilane (5) gave piperidine derivatives 6.It was applied to the synthesis of piperidine, indolizidine, quinolizidine, 1-azabicycloundecane, 1-aza-8-oxabicyclononane, 8-azabicyclooctane, and 9-azabicyclononane derivatives.
Synthesis of 5-fluorouracil derivatives having N-acylazacycloakanes and lactams
Nishitani,Horikawa,Iwasaki,et al.
, p. 1706 - 1712 (2007/10/02)
-
