63874-50-0

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 2-(2-ethoxyphenyl)-1,4-dihydro-4-oxo-, ethyl ester
• CAS NO: 63874-50-0
• Molecular Formula: C15H16N2O4
• Molecular Weight: 288.303
• Mol File: 63874-50-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 2-(2-ethoxyphenyl)-1,4-dihydro-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 2-(2-ethoxyphenyl)-1,4-dihydro-4-oxo-, ethyl ester(63874-50-0)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 2-(2-ethoxyphenyl)-1,4-dihydro-4-oxo-, ethyl ester(63874-50-0)

Safety Data

• Hazardous Substances Data: 63874-50-0(Hazardous Substances Data)

Upstream product

• 53623-81-7 2-Ethoxybenzamidine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 63874-22-6 2-ethoxybenzamidine fluorosulfonate 
• 18637-00-8 2-ethoxy-benzamidine hydrochloride 
• 938-73-8 2-ethoxybenzamide 

Downstream Products

• 63874-78-2 Potassium 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxylate 
• 63874-75-9 2-(5-dimethylamino-2-ethoxy-phenyl)-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid 
• 63874-61-3 2-(5-amino-2-ethoxy-phenyl)-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 63874-60-2 2-(2-ethoxy-5-nitro-phenyl)-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 64801-29-2 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carbonitrile 
• 64633-91-6 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxamide 

Relevant articles and documents

Antiallergy agents. I. 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters

The synthesis of some 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters with potent oral and intravenous antiallergic activity against passive cutaneous anaphylaxis in the rat is described. Requirements for high activity include a free NH group in the pyrimidinone nucleus and a small to medium size ortho alkoxy or alkenyloxy group on the phenyl ring. It is suggested that in the case of the highly active compounds hydrogen bonding occurs between a nitrogen of the pyrimidine ring and the ethereal oxygen. The nature of this bonding and its possible contribution to an optimum configuration for the molecules is discussed.