63875-50-3Relevant articles and documents
Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases
Cardoso, Sílvia Helena,Guimar?es, Ari Souza,McKerrow, James H.,Silva, Leandro Rocha,da Silva, Elany Barbosa,da Silva-Júnior, Edeildo Ferreira,do Nascimento, Jadiely,do Santos Nascimento, Igor José
, (2021)
Chagas disease and Human African Trypanosomiasis (HAT) are caused by Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain (RhD) are cysteine proteases that share 70% of identity and play vital functions in these parasites.