63878-73-9

Basic information

• Product Name: 2-FLUORO-5-NITROBENZYL ALCOHOL 96
• Synonyms: 2-FLUORO-5-NITROBENZYL ALCOHOL 96;(2-Fluoro-5-nitrophenyl)methanol;2-Fluoro-5-nitrophenyl alcohol;2-Fluoro-5-nitronbenzyl alcohol;2-Fluoro-5-nitrobenzyl alcohol 96%;2-Fluoro-5-nitrobenzenemethanol
• CAS NO: 63878-73-9
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.126
• Product Categories: Alcohols;C7 to C8;Oxygen Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C7;C7 to C8;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Oxygen Compounds
• Mol File: 63878-73-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 68-71 °C(lit.)
• Boiling Point: 319°C at 760 mmHg
• Flash Point: 146.8°C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 0.000145mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-FLUORO-5-NITROBENZYL ALCOHOL 96(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-NITROBENZYL ALCOHOL 96(63878-73-9)
• EPA Substance Registry System: 2-FLUORO-5-NITROBENZYL ALCOHOL 96(63878-73-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 63878-73-9(Hazardous Substances Data)

Usage

Description

2-Fluoro-5-nitrobenzyl alcohol, with the chemical formula C7H6FNO3, is an organic compound derived from 2-fluoro-5-nitrobenzaldehyde. It is a versatile intermediate in the synthesis of various chemical compounds and has potential applications in different industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
2-Fluoro-5-nitrobenzyl alcohol is used as a synthetic intermediate for the production of 2-fluoro-5-nitrobenzyl bromide, which is an important compound in the development of pharmaceuticals. The synthesis of this intermediate allows for the creation of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-fluoro-5-nitrobenzyl alcohol is used as a precursor to synthesize 5-amino-2-fluorobenzyl alcohol. 2-FLUORO-5-NITROBENZYL ALCOHOL 96 can be further utilized in the development of various chemical products, showcasing the versatility of 2-fluoro-5-nitrobenzyl alcohol as a synthetic building block.
Used in Research and Development:
2-Fluoro-5-nitrobenzyl alcohol also finds application in research and development, where it can be employed to study the properties and reactivity of fluorinated aromatic compounds. This knowledge can be applied to design and develop new molecules with specific functionalities and applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C7H6FNO3/c8-7-2-1-6(9(11)12)3-5(7)4-10/h1-3,10H,4H2

Upstream product

• 27996-87-8 2-fluoro-5-nitrobenzaldehye 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 83141-10-0 2,6-difluoro-3-nitrobenzoic acid 
• 84832-01-9 methyl 2,6-difluoro-3-nitrobenzoate 

Downstream Products

• 63878-68-2 1-fluoro-2-(fluoromethyl)-4-nitrobenzene 
• 1039881-87-2 (2-(4-ethylpiperazin-1-yl)-5-nitrophenyl)methanol 
• 844893-02-3 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester 
• 480461-26-5 2-[4-(2-bromo-5-nitrobenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 
• 943513-67-5 1-cyclohexyl-2-{4-[5-(1,1-dioxoisothiazolidin-2-yl)-2-morpholin-4-yl-benzyloxy]-2-fluorophenyl}-1H-benzimidazole-5-carboxylic acid methyl ester 
• 943513-68-6 C₃₇H₄₁FN₄O₅ 
• 844891-82-3 2-{4-[5-(acetylamino)-2-morpholin-4-ylbenzyloxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 
• 844891-83-4 2-[4-(5-(acetyl)(methyl)amino-2-morpholin-4-ylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 
• 943513-36-8 C₃₄H₃₅FN₄O₇ 
• 943513-69-7 C₃₆H₄₁FN₄O₆ 
• 943513-60-8 1-cyclohexyl-2-[2-fluoro-4-(5-isopropylamino-2-morpholin-4-ylbenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester 
• 943513-70-0 2-{4-[5-(acetyl)(isopropyl)amino-2-morpholin-4-ylbenzyloxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-carboxylic acid methyl ester 
• 943513-37-9 C₃₃H₃₆FN₅O₅ 
• 943513-38-0 C₃₄H₃₆FN₅O₆ 

Relevant articles and documents

CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R1, R2, R3, Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

New hits as antagonists of GPR103 identified by HTS

Preclinical data indicate that GPR103 receptor and its endogenous neuropeptides QRFP26 and QRFP43 are involved in appetite regulation. A high throughput screening (HTS) for small molecule GPR103 antagonists was performed with the clinical goal to target weight management by modulation of appetite. A high hit rate from the HTS and initial low confirmation with respect to functional versus affinity data challenged us to revise the established screening cascade. To secure high quality data while increasing throughput, the binding assay was optimized on quality to run at single concentration. This strategy enabled evaluation of a larger fraction of chemical clusters and singletons delivering 17 new compound classes for GPR103 antagonism. Representative compounds from three clusters are presented. One of the identified clusters was further investigated, and an initial structure-activity relationship study is reported. The most potent compound identified had a pIC50 of 7.9 with an improved ligand lipophilic efficiency.

7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS

The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.