63909-10-4

Basic information

• Product Name: 5'-ETHYL-2'-HYDROXYPROPIOPHENONE
• Synonyms: 5'-ETHYL-2'-HYDROXYPROPIOPHENONE
• CAS NO: 63909-10-4
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• Mol File: 63909-10-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5'-ETHYL-2'-HYDROXYPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-ETHYL-2'-HYDROXYPROPIOPHENONE(63909-10-4)
• EPA Substance Registry System: 5'-ETHYL-2'-HYDROXYPROPIOPHENONE(63909-10-4)

Safety Data

• Hazardous Substances Data: 63909-10-4(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of 4-ethylphenyl propionate with aluminium chloride at 100° for 2 h (70%) or at 170° for 1–2 h (80–96%).

Upstream product

• 54549-71-2 propionic acid-(4-ethyl-phenyl ester) 
• 123-07-9 4-Ethylphenol 
• 79-03-8 propionyl chloride 

Downstream Products

• 70978-47-1 5-Ethyl-2-hydroxy-3-nitro-propiophenon 
• 70978-24-4 3-Amino-5-ethyl-2-hydroxy-propiophenon 
• 70978-28-8 5-Ethyl-2-hydroxy-3-propionyl-cyanoformanilid 

Relevant articles and documents

2'Hydroxy tetrazole-5-carboxanilides and anti-allergic use thereof

New tetrazole derivatives of the general formula: STR1 [wherein R1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula: (wherein R2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 5 carbon atoms, an aryl, aralkyl or trifluoromethyl group, or a cycloalkyl group containing from 3 to 8 carbon atoms, and R3 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms optionally substituted by a phenyl group, or represents an aryl group optionally substituted by one or more substituents selected from halogen atoms and straight- or branched-chain alkyl and alkoxy groups containing from 1 to 6 carbon atoms and hydroxy, trifluoromethyl and nitro groups), and m represents zero or an integer 1, 2 or 3, the substituents R1 being the same or different when m represents 2 or 3] possess pharmacological properties, in particular properties of value in the treatment of allergic conditions.