639091-75-1

Basic information

• Product Name: 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester
• Synonyms: 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester;Methyl 2-(Boc-amino)isonicotinate;4-Pyridinecarboxylic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester;Methyl 2-((tert-butoxycarbonyl)aMino)isonicotinate;2-Boc-amino-isonicotinic acid methyl ester;2-tert-Butoxycarbonylamino-isonicotinic acid methyl ester
• CAS NO: 639091-75-1
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.26644
• Mol File: 639091-75-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 75.1～75.2℃
• Boiling Point: 325.534°C at 760 mmHg
• Flash Point: 150.678°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.12±0.70(Predicted)
• CAS DataBase Reference: 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester(639091-75-1)
• EPA Substance Registry System: 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester(639091-75-1)

Safety Data

• Hazardous Substances Data: 639091-75-1(Hazardous Substances Data)

Usage

General Description

The chemical 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester is a compound that consists of a pyridine ring with a carboxylic acid group and a methyl ester group attached at the 4th and 2nd positions, respectively. It also contains an amino group with a dimethylethoxy carbonyl protective group attached at the 1st position. 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester may have potential applications in medicinal chemistry, as it contains functional groups that are commonly found in pharmaceutical compounds, and it could potentially be used as a building block or intermediate in the synthesis of other pharmaceutical agents. Further research and testing would be needed to determine the specific properties and potential uses of this compound.

InChI:InChI=1/C12H16N2O4/c1-12(2,3)18-11(16)14-9-7-8(5-6-13-9)10(15)17-4/h5-7H,1-4H3,(H,13,14,16)

Upstream product

• 67-56-1 methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13362-28-2 2-aminoisonicotinic acid 
• 6313-54-8 2-chloroisonicotinic acid, 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 

Downstream Products

• 304873-62-9 (4-hydroxymethylpyridin-2-yl)carbamic acid tert-butyl ester 
• 639091-78-4 tert-butyl [4-(aminomethyl)pyridin-2-yl]carbamate 
• 639091-77-3 tert-butyl {4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]pyridin-2-yl}carbamate 
• 1417342-99-4 5,8-dimethyl-2-(2-phenylimidazo[1,2-a]pyridin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine 
• 1417343-24-8 2-(2-(3-bromophenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine 
• 1417343-25-9 2-(2-(3-cyclopropylphenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine 
• 1417343-26-0 5,8-dimethyl-2-(2-(3-(pyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine 
• 1417343-27-1 (S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine 
• 1446252-28-3 (Z)-4-(4-fluorostyryl)-pyridin-2-amine 
• 1446252-29-4 (Z)-tert-butyl 4-(4-fluorostyryl)pyridin-2-yl(isopropyl)carbamate 
• 1446252-30-7 (Z)-4-(4-fluorostyryl)-N-isopropylpyridin-2-amine 

Relevant articles and documents

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament; a pharmaceutical composition containing the same, and a treatment method using the composition; and a preparation method thereof. The novel compound, the isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION

Compounds of formulae (I) and (II), compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells invivo, in vitro, or ex vivo.

A multifunctional reagent designed for the site-selective amination of pyridines

We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site selectivity and chemoselectivity. The novel reagent was prepared on 200-g scale in a single step, reacts in the title reaction under mild conditions without precautions toward air or moisture, and is tolerant of nearly all common functionality. Experimental and in situ spectroscopic monitoring techniques provide detailed insights and unexpected findings for the unique reaction mechanism.