63916-59-6

Basic information

• Product Name: MORPHOLINE, 4-PIPERONYLOYL-
• Synonyms: MORPHOLINE, 4-PIPERONYLOYL-;4-(1,3-Benzodioxol-5-ylcarbonyl)morpholine;Brn 1219623;Morpholine, 4-(1,3-benzodioxol-5-ylcarbonyl)-;N-(3,4-Methylenedioxybenzoyl)morpholine;Piperonylic acid, morpholide;1,3-benzodioxol-5-yl(morpholin-4-yl)methanone
• CAS NO: 63916-59-6
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.2359
• Mol File: 63916-59-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 430.2°Cat760mmHg
• Flash Point: 214°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 1.32E-07mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: MORPHOLINE, 4-PIPERONYLOYL-(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLINE, 4-PIPERONYLOYL-(63916-59-6)
• EPA Substance Registry System: MORPHOLINE, 4-PIPERONYLOYL-(63916-59-6)

Safety Data

• Hazardous Substances Data: 63916-59-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H13NO4/c14-12(13-3-5-15-6-4-13)9-1-2-10-11(7-9)17-8-16-10/h1-2,7H,3-6,8H2

Upstream product

• 110-91-8 morpholine 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 94-53-1 Piperonylic acid 
• 495-76-1 piperonol 
• 102132-54-7 1,3-benzodioxole-5-carboxylic acid 2,5-dioxo-1-pyrrolidinyl ester 
• 120-57-0 piperonal 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 

Downstream Products

• 93363-39-4 2-(3,4-methylenedioxybenzoyl)-5-(2-phenylethyl)pyrrole 
• 6327-54-4 benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methanone 
• 96999-25-6 2-Benzo[1,3]dioxol-5-ylmethyl-5-phenethyl-1H-pyrrole 

Relevant articles and documents

Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide

An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.

Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives

A series of benzamide derivatives such as 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP) were synthesized by the reaction of substituted benzoic acids with piperidine, morpholine or pyrrolidine using a novel method. The crystals of these benzamide de

Synthesis of phenstatin and prodrugs thereof

A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a dibenzylphosphite