6392-26-3

Basic information

• Product Name: (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE
• Synonyms: (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE;4-(2-CHLOROBENZOYL)-MORPHOLINE
• CAS NO: 6392-26-3
• Molecular Formula: C₁₁H₁₂ClNO₂
• Molecular Weight: 225.67148
• Mol File: 6392-26-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 382.1°C at 760 mmHg
• Flash Point: 184.9°C
• Appearance: /
• Density: 1.271g/cm³
• Vapor Pressure: 4.83E-06mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE(6392-26-3)
• EPA Substance Registry System: (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE(6392-26-3)

Safety Data

• Hazardous Substances Data: 6392-26-3(Hazardous Substances Data)

Usage

Description

(2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE, also known as 2-Chloromorpholine-4-carbaldehyde, is a chemical compound with the molecular formula C10H13ClN2O2. It is a derivative of morpholine and is classified as a ketone. (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE is characterized by the presence of a chloro group and a morpholine ring in its structure, making it a potentially important building block for the development of new drugs with diverse biological activities.

Uses

Used in Pharmaceutical Industry:
(2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs with diverse biological activities. Its unique structure, including the chloro group and morpholine ring, allows for the creation of compounds that can target specific biological pathways or receptors.
Used in Agrochemical Industry:
(2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE is also used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides or other agricultural products. Its chemical properties make it a valuable component in creating effective and targeted agrochemicals.
It is important to handle (2-CHLORO-PHENYL)-MORPHOLIN-4-YL-METHANONE with care, as it may pose health and environmental hazards. Proper safety measures should be taken during its production, use, and disposal to minimize any potential risks.

InChI:InChI=1/C11H12ClNO2/c12-10-4-2-1-3-9(10)11(14)13-5-7-15-8-6-13/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 609-65-4 o-chlorobenzoyl chloride 
• 15159-40-7 4-morpholinocarbonyl chloride 
• 346656-42-6 2-(2-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 118-91-2 ortho-chlorobenzoic acid 
• 68388-08-9 2-chlorobenzoic acid N-hydroxysuccinimide ester 
• 89-98-5 2-chloro-benzaldehyde 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 23328-69-0 4-chloromorpholine 
• 95-49-8 2-methylchlorobenzene 
• 615-41-8 2-iodochlorobenzene 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 6391-91-9 o-chlorobenzothiomorpholide 
• 1386231-41-9 potassium 2-(morpholine-4-carbonyl)phenyltrifluoroborate 
• 874219-17-7 [2-(morpholin-4-ylcarbonyl)phenyl]boronic acid 
• 1400974-96-0 4'-(1H-pyrrol-1-yl)([1,1'-biphenyl]-2-yl)(morpholino)methanone 
• 622370-35-8 [2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-(4-pyridinyl)-1H-1,2,3-triazol-4-yl]-3-pyridinyl](2-chlorophenyl)-methanone 
• 622372-89-8 (2-bromo-pyridin-3-yl)-(2-chloro-phenyl)-methanone 

Relevant articles and documents

Solar and visible-light active nano Ni/g-C3N4photocatalyst for carbon monoxide (CO) and ligand-free carbonylation reactions

In this study, we investigate the amino and alkoxycarbonylation reaction between various substituted aryl halides, benzyl iodides, and iodocyclohexane with different types of amines and alcohols in the absence of carbon monoxide gas and ligands. Similar reactions are carried out at high temperatures, in the presence of appropriate ligands, stoichiometric amounts of bases, and gaseous carbon monoxide, which endanger the health of organic chemists. We present a novel method that does not utilize ligands, bases, gaseous CO, and special conditions. This procedure is a redox reaction carried out by new economic nano Ni/g-C3N4at room temperature and under visible light. Mo(CO)6was used toin situgenerate CO, to resolve the problems caused by the use of CO gas. This protocol has the ability to be used on a gram scale by using a continuous flow reactor.

Carbon bridged bis-amide-based rare-earth amine compound and its preparation and with [...][...] synthesis reaction in the application of the

The invention discloses a carbon-bridged diacylamino rare earth amide with a general formula of {LLn[N(SiMe3)2]}2, wherein Ln is a rare earth metal selected from lanthanum, neodymium, samarium and yttrium, L represents a carbon-bridged diacylamino ligand, and n may be 1, 2 or 3 and can represent different ligands. The chemical structural formula of the carbon-bridged diacylamino rare earth amide differs with changes of the rare earth metal and the ligand. The invention targetedly discloses four chemical structural formulas of the rare earth amide as shown in the general formula. The carbon-bridged diacylamino rare earth amide provided by the invention is simple to synthesize, has definite structure and high yield and is easy to separate and purify. The invention also provides a preparation method for the rare earth amide and a method for applying the rare earth amide as a catalyst for catalysis of amidation of aldehyde and amine. The application method has the advantages of mild conditions, high activity, good selectivity, a wide substrate adaptation scope, a small catalyst amount and high product yield.

Ortho lithiation-in situ borylation of substituted morpholine benzamides

Morpholine amides are cheap and safe alternative to Weinreb amides as acylating agents of organometallic species. Herein, the in-situ lithiation/borylation of 18 ortho- meta- and para-substituted morpholine benzamides has been investigated. 10 of the 18 substrates provided the desired boronic esters as the major isomer (>90% regioselectivity) in crude isolated yields ranging from 68 to 93%. The synthetic usability of such building blocks was subsequently illustrated via the synthesis of a kinase inhibitor.