639496-93-8

Basic information

• Product Name: 1-(2-methoxyethyl)-4-[4'-(3,3,4,4,4-pentafluorobutyl)biphenyl-4-sulfonyl]piperidine-4-carboxylic acid tert-butyl ester
• Synonyms: 1-(2-methoxyethyl)-4-[4'-(3,3,4,4,4-pentafluorobutyl)biphenyl-4-sulfonyl]piperidine-4-carboxylic acid tert-butyl ester
• CAS NO: 639496-93-8
• Molecular Weight: 605.667
• Mol File: 639496-93-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-methoxyethyl)-4-[4'-(3,3,4,4,4-pentafluorobutyl)biphenyl-4-sulfonyl]piperidine-4-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxyethyl)-4-[4'-(3,3,4,4,4-pentafluorobutyl)biphenyl-4-sulfonyl]piperidine-4-carboxylic acid tert-butyl ester(639496-93-8)
• EPA Substance Registry System: 1-(2-methoxyethyl)-4-[4'-(3,3,4,4,4-pentafluorobutyl)biphenyl-4-sulfonyl]piperidine-4-carboxylic acid tert-butyl ester(639496-93-8)

Safety Data

• Hazardous Substances Data: 639496-93-8(Hazardous Substances Data)

Upstream product

• 639496-88-1 [4'-(3,3,4,4,4-pentafluorobutyl)biphenyl-4-sulfonyl]acetic acid tert-butyl ester 
• 26112-92-5 bis-(2-chloro-ethyl)-(2-methoxy-ethyl)-amine 

Downstream Products

• 639496-95-0 1-(2-methoxyethyl)-4-[4'-(3,3,4,4,4-pentafluorobutyl)biphenyl-4-sulfonyl]piperidine-4-carboxylic acid 

Relevant articles and documents

ARYLSULFONYLHYDROXAMIC ACID AND AMIDE DERIVATIVES AND THEIR USE AS PROTEASE INHIBITORS

This invention is directed generally to hydroxamic acid and amide compounds (including salts of such compounds), and, more particularly, to aryl- and heteroaryl--arylsulfonylmethyl hydroxamic acids and amides that, inter alia, inhibit protease activity, particularly matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. These compounds generally correspond in structure to formula (I): wherein Al, A2, A3, El, E2, E3, and E4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly pathological conditions.