639517-84-3

Basic information

• Product Name: 2-(2-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE
• Synonyms: 2-(2-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE;2-(2-chlorophenyl)-1,3-thiazole-4-carbaldehyde
• CAS NO: 639517-84-3
• Molecular Formula: C₁₀H₆ClNOS
• Molecular Weight: 223.68
• Mol File: 639517-84-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 386.702°C at 760 mmHg
• Flash Point: 187.671°C
• Appearance: /
• Density: 1.389g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.28±0.50(Predicted)
• CAS DataBase Reference: 2-(2-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(639517-84-3)
• EPA Substance Registry System: 2-(2-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(639517-84-3)

Safety Data

• Hazardous Substances Data: 639517-84-3(Hazardous Substances Data)

Usage

General Description

2-(2-Chloro-phenyl)-thiazole-4-carbaldehyde is a complex organic compound that belongs to the class of organic compounds known as thiazole carbonyl compounds. These compounds contain a thiazole ring, which is a heterocyclic ring made up of one sulfur atom, one nitrogen atom, and three carbon atoms, where one of the carbon atoms carries a carbonyl group. The phenyl group in its structure indicates the presence of a benzene ring. The presence of the chloro group suggests that there is at least one chlorine atom incorporated in the molecular structure. 2-(2-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE is used in the field of organic synthesis, serving as a base chemical structure in the creation of various other compounds. Specific properties such as the boiling point, melting point, and toxicity can vary and depend on how this chemical is synthesized and its pure form.

InChI:InChI=1/C10H6ClNOS/c11-9-4-2-1-3-8(9)10-12-7(5-13)6-14-10/h1-6H

Upstream product

• 132089-36-2 ethyl 2-(2-chlorophenyl)thiazole-4-carboxylate 
• 639517-86-5 2-(2-chlorophenyl)-4-hydroxymethylthiazole 
• 588676-51-1 4-chloromethyl-2-(2-chloro-phenyl)-thiazole 
• 873-32-5 2-Chlorobenzonitrile 
• 15717-17-6 2-chlorothiobenzamide 

Downstream Products

• 1187020-65-0 4-[2-(2-chlorophenylthiazol)-4-yl]-2,6-dimethyl-3,5-diacethyl-1,4-dihydropyridine 
• 1187020-69-4 4-[2-(2-chlorophenylthiazol)-4-yl]-2,6-dimethyl-3,5-dibenzoyl-1,4-dihydropyridine 
• 1244030-72-5 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene 

Relevant articles and documents

Synthesis and in-vitro cytotoxicity of poly-functionalized 4-(2-arylthiazol-4-yl)-4H-chromenes

A new series of 4-aryl-4H-chromenes bearing a 2-arylthiazol-4-yl moiety at the 4-position were prepared as potential cytotoxic agents. The in-vitro cytotoxic activity of the synthesized 4-aryl-4H-chromenes was investigated in comparison with etoposide, a well-known anticancer drug, using MTT colorimetric assay. Among them, the 2-(2-chlorophenyl)thiazol-4-yl analog 4b showed the most potent activity against nasopharyngeal epidermoid carcinoma KB, medulloblastoma DAOY, and astrocytoma 1321N1, and compound 4d bearing a 2-(4-chlorophenyl) thiazol-4-yl moiety at the 4-position of the chromene ring exhibited the best inhibitory activity against breast cancer cells MCF-7, lung cancer cells A549, and colon adenocarcinoma cells SW480 with IC50 values less than 5 μM. The ability of compound 4b to induce apoptosis was confirmed in a nuclear morphological assay by DAPI staining in the KB and MCF-7 cells.

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