63975-98-4Relevant articles and documents
Method for preparing L-muscone
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Paragraph 0046; 0049, (2020/04/02)
The invention discloses a method for preparing L-muscone. The method comprises the following steps: (1) L-muscone in racemic muscone and a chiral hydroxybenzene compound generate L-enantiomer salt under laser irradiation; and (2) crystallization separation and hydrolysis are performed on the L-enantiomer salt to obtain a L-muscone product, wherein the step (1) is carried out in the presence of a Bronsted acid catalyst. Preferably, after hydrolysis in the step (2), separation, purification and other steps are carried out to obtain the L-muscone product. The raw material used in the method is the racemic muscone with a mature production process; batch production can be realized, diastereomer salifying resolution is carried out by adopting laser irradiation, the product selectivity is greatlyimproved, the method is green, pollution-free, and less in production of three wastes, the chiral hydroxybenzene compound is convenient to recover and reusable, the atom economy is high, the productselectivity is high, and the method is suitable for being used in the fields of biology, medical treatment, medicines, spices, cosmetics and the like.
(E)-3-METHYL-2-CYCLOALKENONE COMPOUND, 3-HALO-3-METHYLCYCLOALKANONE COMPOUND AND METHOD FOR PRODUCING (R)-3-METHYLCYCLOALKANONE COMPOUND
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Paragraph 0268-0271; 0290; 0291, (2018/06/29)
PROBLEM TO BE SOLVED: To provide novel (E)-3-methyl-2-cycloalkenone compounds and 3-halo-3-methylcycloalkanone compounds, and also provide a production method that can efficiently produce (R)-3-methylcycloalkanone compounds. SOLUTION: An (E)-3-methyl-2-cycloalkenone compound has a chemical structure represented by the following formula (1) (where n is an integer of 1-5, 7 or 8). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
PROCESS FOR PRODUCTION OF 3-METHYL-CYCLOPENTADECENONE, PROCESS FOR PRODUCTION OF R/S-MUSCONE, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE MUSCONE
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Page/Page column 9, (2012/02/14)
By intramolecular condensation reaction of 2,15-hexadecanedione in a gaseous phase with a compound of a Group II element of the Periodic Table as a catalyst, 3-methyl-cyclopentadecenones is generated. Magnesium oxide, calcium oxide, or zinc oxide is desirable as the catalyst for the intramolecular condensation reaction. (R)- and (S)-muscone is generated by subjecting 3-methyl-cyclopentadecenones obtained as above to hydrogenation by using a catalyst. Palladium catalyst is desirable as the hydrogenation catalyst. Optically active muscone is generated by separating 3-methyl-cyclopentadecenones into respective components thereof by means of precision distillation and subsequently subjecting the separated 3-methyl-cyclopentadecenones to asymmetric hydrogenation by using an optically active ruthenium complex catalyst. The production methods described above enable easy and economical production of 3-methyl-cyclopentadecenones, (R)-and (S)-muscone, and optically active muscone.
