63981-45-3

Basic information

• Product Name: 2-Methyl-1,4-piperazinedicarboxylic acid diethyl ester
• Synonyms: 2-Methyl-1,4-piperazinedicarboxylic acid diethyl ester
• CAS NO: 63981-45-3
• Molecular Formula: C11H20 N2 O4
• Molecular Weight: 244.29
• Mol File: 63981-45-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 323.5°C at 760 mmHg
• Flash Point: 149.5°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 0.000261mmHg at 25°C
• Refractive Index: 1.478
• CAS DataBase Reference: 2-Methyl-1,4-piperazinedicarboxylic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1,4-piperazinedicarboxylic acid diethyl ester(63981-45-3)
• EPA Substance Registry System: 2-Methyl-1,4-piperazinedicarboxylic acid diethyl ester(63981-45-3)

Safety Data

• Hazardous Substances Data: 63981-45-3(Hazardous Substances Data)

Usage

General Description

2-Methyl-1,4-piperazinedicarboxylic acid diethyl ester is a chemical compound with the molecular formula C12H22N2O4. It is a diethyl ester derivative of 2-methyl-1, 4-piperazinedicarboxylic acid and is commonly used as a building block in the synthesis of pharmaceuticals and organic compounds. It is a white crystalline solid that is soluble in organic solvents and has a melting point of around 110-112°C. 2-Methyl-1,4-piperazinedicarboxylic acid diethyl ester is used in various industries, including pharmaceuticals, agrochemicals, and material science, for the production of a range of products.

InChI:InChI=1/C11H20N2O4/c1-4-16-10(14)12-6-7-13(9(3)8-12)11(15)17-5-2/h9H,4-8H2,1-3H3

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 109-07-9 (RS)-2-methylpiperazine 

Downstream Products

• 120737-73-7 ethyl 2-methyl-1-piperazinecarboxylate 

Relevant articles and documents

Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs

Nitric oxide (NO) prodrugs such as O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) are a growing class of promising NO-based therapeutics. Nitric oxide release from the anti-cancer lead compound, JS-K, is proposed to occur through a nucleophilic aromatic substitution by glutathione (GSH) catalyzed by glutathione S-transferase (GST) to form a diazeniumdiolate anion that spontaneously releases NO. In this study, a number of structural analogues of JS-K were synthesized and their chemical and biological properties were compared with those of JS-K. The homopiperazine analogue of JS-K showed anti-cancer activity that is comparable with that of JS-K but with a diminished reactivity towards both GSH and GSH/GST; both the aforementioned compounds displayed no cytotoxic activity towards normal renal epithelial cell line at concentrations where they significantly diminished the proliferation of a panel of renal cancer cell lines. These properties may prove advantageous in the further development of this class of nitric oxide prodrugs as cancer therapeutic agents.