639863-84-6

Basic information

• Product Name: 1-(isocyanatomethyl)-4-(propan-2-yloxy)benzene
• Synonyms: 1-(isocyanatomethyl)-4-(propan-2-yloxy)benzene
• CAS NO: 639863-84-6
• Molecular Weight: 191.23
• Mol File: 639863-84-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(isocyanatomethyl)-4-(propan-2-yloxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(isocyanatomethyl)-4-(propan-2-yloxy)benzene(639863-84-6)
• EPA Substance Registry System: 1-(isocyanatomethyl)-4-(propan-2-yloxy)benzene(639863-84-6)

Safety Data

• Hazardous Substances Data: 639863-84-6(Hazardous Substances Data)

Upstream product

• 55784-07-1 4-hydroxyphenylacetic acid isopropyl ether 

Downstream Products

• 706779-91-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide 

Relevant articles and documents

METHOD FOR THE PREPARATION OF PIMAVANSERIN BASE

Disclosed is a process for the synthesis of pimavanserin base with a high yield and purity, which comprises: a) converting tert-butyl-N-[(4-propan-2-yloxyphenyl)methyl]carbamate (Formula (I)) to 1-(isocyanatomethyl)-4-propan-2-yloxybenzene of formula (II) b) adding N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine (Formula (IV)) to the solution obtained in a) to give pimavanserin base, and c) purifying the pimavanserin base obtained in step b).

USE OF 4-AMINO-PIPERIDINES FOR TREATING SLEEP DISORDERS

Inverse agonists and antagonists of serotonin receptors are disclosed for use in treating sleep disorders such as insomnia, and specifically sleep maintenance insomnia. The compound increase slow wave sleep, decrease the number of awakenings after sleep onset, and decrease the time awake after sleep onset.