64019-58-5

Basic information

• Product Name: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)ACETOHYDRAZIDE
• Synonyms: 1H-Pyrazole-1-aceticacid, 3,5-diMethyl-, hydrazide
• CAS NO: 64019-58-5
• Molecular Formula: C₇H₁₂N₄O
• Molecular Weight: 168.2
• Mol File: 64019-58-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 383.1°C at 760 mmHg
• Flash Point: 185.5°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 4.51E-06mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)ACETOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)ACETOHYDRAZIDE(64019-58-5)
• EPA Substance Registry System: 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)ACETOHYDRAZIDE(64019-58-5)

Safety Data

• Hazardous Substances Data: 64019-58-5(Hazardous Substances Data)

Usage

Type of compound

Hydrazide derivative

Usage

Commonly used in pharmaceutical and research settings

Functionality

Acts as a synthetic intermediate in the production of various organic compounds

Pharmacological properties

Potential ability to inhibit enzymes and act as a drug candidate for the treatment of various diseases

Potential applications

Role in the development of new materials and its applications in chemical synthesis and catalysis

InChI:InChI=1/C7H12N4O/c1-5-3-6(2)11(10-5)4-7(12)9-8/h3H,4,8H2,1-2H3,(H,9,12)

Upstream product

• 10199-60-7 ethyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 123-54-6 acetylacetone 

Downstream Products

• 87013-85-2 C₁₄H₂₃N₅O₂ 
• 87013-86-3 C₁₅H₁₉N₅O₂ 
• 1143582-85-7 N'-(3-hydroxy-4-methoxybenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 342634-97-3 N'-(4-methylbenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 342637-46-1 N'-(4-fluorobenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 342637-52-9 N'-(4-chlorobenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 345647-97-4 N'-(4-hydroxybenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 344927-46-4 N'-(4-methoxybenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 342621-93-6 N'-(4-bromobenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 350033-45-3 N'-(2-fluorobenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 349641-81-2 N'-(3-methoxybenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 342421-76-5 N'-(4-(dimethylamino)benzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 1143582-83-5 N'-(2-bromobenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 
• 1143582-84-6 N'-(2-nitrobenzylidene)-2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide 

Relevant articles and documents

Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment

A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition profile (SI of 264) not far of Celecoxib (2 9 4). In-vivo anti-inflamm

Synthesis and anti-inflammatory activity of some pyrazole derivatives

A novel series of pyrazoles containing benzenesulfonamides, 1,3,4-oxadiazole-2-thiones, 4-substituted-1,2,4-triazole-3-thiones, and 2-substituted-1,3,4-thiadiazoles has been synthesized. Anti-inflammatory activity of some synthesized compounds was evaluated in vivo utilizing a standard acute carrageenan-induced paw edema method. The most active anti-inflammatory agents 3, 8f, and 10f were evaluated for ulcerogenic liability in rats compared to indomethacin and celecoxib as reference standards. Molecular modeling studies were initiated herein to validate the attained pharmacological data and provide understandable evidence for the observed anti-inflammatory behavior.

Synthesis and biological activities of novel bis-heterocyclic pyrrodiazole derivatives

Novel structures of bis-heterocyclic pyrrodiazole derivatives containing pyrazole were designed and synthesized. The title compounds were characterized by 1H NMR, IR, MS, and elemental analysis. Biological activities of three intermediate compounds and 25 pyrrodiazole derivatives were tested in vivo and in vitro. Some of the title compounds exhibited certain herbicidal activities against barnyardgrass and rape.