64035-67-2

Basic information

• Product Name: 1-Propanol, 3-(methyldiphenylsilyl)-
• CAS NO: 64035-67-2
• Molecular Formula: C16H20OSi
• Molecular Weight: 256.42
• Mol File: 64035-67-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Propanol, 3-(methyldiphenylsilyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 3-(methyldiphenylsilyl)-(64035-67-2)
• EPA Substance Registry System: 1-Propanol, 3-(methyldiphenylsilyl)-(64035-67-2)

Safety Data

• Hazardous Substances Data: 64035-67-2(Hazardous Substances Data)

Upstream product

• 917-54-4 methyllithium 
• 18146-00-4 allyloxytrimethylsilane 
• 776-76-1 methyldiphenylsilane 

Relevant articles and documents

The S(H)i reaction at silicon - A new entry into cyclic alkoxysilanes

A new mild radical method for the preparation of cyclic five-membered alkoxysilanes is reported. This method comprises an intramolecular homolytic substitution reaction at silicon (S(H)i). Various leaving groups (SiMe3, GeMe3, SnMe3) were tested in the homolytic substitution reaction. We found that high yields were only obtained for silanes bearing a trimethyl-stannyl functionality as leaving group in the S(H)i reaction. Rate constants for the cyclization reaction were estimated by conducting standard competition experiments. Based on the kinetic data, more elaborate reaction sequences such as radical addition reactions with a subsequent S(H)i step were carried out. Stereoselective cyclization reactions were also investigated. Excellent 1,2 diastereoselectivities were observed. The products of the S(H)i reaction, cyclic alkoxysilanes, can easily be converted to the corresponding diol derivatives by Tamao-Fleming oxidation as demonstrated for several examples.