64037-14-5 Usage
Description
5-Methoxy-2-benzoxazolamine is a chemical compound with the molecular formula C9H9NO2. It is a derivative of benzoxazole and contains a methoxy group at the 5-position of the benzene ring. 5-Methoxy-2-benzoxazolamine has been studied for its potential use in pharmaceuticals and as a fluorescent dye, exhibiting properties such as anti-inflammatory and antioxidant capabilities in preclinical studies. Furthermore, it has been utilized in the synthesis of various heterocyclic compounds and serves as a building block in organic chemistry.
Uses
Used in Pharmaceutical Industry:
5-Methoxy-2-benzoxazolamine is used as a pharmaceutical agent for its potential anti-inflammatory and antioxidant properties, which have been demonstrated in preclinical studies. These characteristics make it a promising candidate for the development of new drugs targeting inflammation and oxidative stress-related conditions.
Used in Materials Science:
In the field of materials science, 5-Methoxy-2-benzoxazolamine is used as a fluorescent dye due to its optical properties. This application allows it to be employed in various research and diagnostic techniques that require the visualization and tracking of specific molecules or cellular processes.
Used in Chemical Synthesis:
5-Methoxy-2-benzoxazolamine is used as a building block and synthetic intermediate in organic chemistry. Its unique structure and functional groups make it a valuable component in the synthesis of a wide range of heterocyclic compounds, which are essential in various chemical and pharmaceutical applications.
Used in Research Applications:
5-Methoxy-2-benzoxazolamine is also used in research settings to explore its potential applications and properties further. Studies on 5-Methoxy-2-benzoxazolamine contribute to the advancement of knowledge in medicinal chemistry, materials science, and the development of new synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 64037-14-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,0,3 and 7 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 64037-14:
(7*6)+(6*4)+(5*0)+(4*3)+(3*7)+(2*1)+(1*4)=105
105 % 10 = 5
So 64037-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2O2/c1-11-5-2-3-7-6(4-5)10-8(9)12-7/h2-4H,1H3,(H2,9,10)
64037-14-5Relevant articles and documents
Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors
An, Ying,Lee, Eun,Yu, Yeongji,Yun, Jieun,Lee, Myeong Youl,Kang, Jong Soon,Kim, Woo-Young,Jeon, Raok
, p. 3067 - 3072 (2016/06/13)
A novel series of benzoxazole analogs was designed and synthesized, and their inhibitory activities against Aurora kinases were evaluated. Some of the tested compounds exhibited a promising activity with respect to the inhibition of Aurora B kinase. A structure-activity relationship study indicated that linker length, regiochemistry, and halogen substitution play important roles in kinase inhibitory potency. The binding modes between representative compounds and Aurora kinases were interpreted through a molecular docking study to explain the inhibitory activity and selectivity for Aurora A and B kinases. Compounds 13l and 13q also show an antiproliferative effect on the human tumor cell lines in a dose-dependent manner. The most potent 13q demonstrated good efficacy in the prostate cancer PC-3 tumor xenograft model.
