640722-80-1

Basic information

• Product Name: 3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-5-(toluene-4-sulfonyl)piperidine-2,6-dione
• Synonyms: 3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-5-(toluene-4-sulfonyl)piperidine-2,6-dione
• CAS NO: 640722-80-1
• Molecular Weight: 438.547
• Mol File: 640722-80-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-5-(toluene-4-sulfonyl)piperidine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-5-(toluene-4-sulfonyl)piperidine-2,6-dione(640722-80-1)
• EPA Substance Registry System: 3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-5-(toluene-4-sulfonyl)piperidine-2,6-dione(640722-80-1)

Safety Data

• Hazardous Substances Data: 640722-80-1(Hazardous Substances Data)

Upstream product

• 503544-97-6 N-[2-(3-indolyl)ethyl]-2-(4-methylphenylsulfonyl)acetamide 
• 98837-36-6 methyl 3-hydroxy-2-methylenebutyrate 
• 22787-68-4 methyl 2-(1-acetoxyethyl)acrylate 
• 3070-65-3 ethyl 2-methylenebutyrate 
• 639007-41-3 3-ethylidene-1-[2-(1H-indol-3-yl)-ethyl]-5-(toluene-4-sulfonyl)-piperidine-2,6-dione 

Downstream Products

• 639007-51-5 5-ethyl-1-[2-(1H-indol-3-yl)ethyl]-3-(toluene-4-sulfonyl)piperidin-2-one 

Relevant articles and documents

One-pot facile conversion of Baylis-Hillman adduct into N-alkyl 3-(E)-alkylidene-5-substituted sulfonylpiperidine-2,6-dione. Formal synthesis of tacamonine

A stepwise [3+3] strategy to N-alkyl 3-(E)-alkylidene-5-substituted sulfonylpiperidine-2,6-dione 1 used various N-alkyl α-substituted sulfonylacetamides 2 and α,β-unsaturated esters 3 as starting materials. α,β-Unsaturated esters 3 were generated by Baylis-Hillman reaction. A ring closure mechanism was proposed for the reactions. This method provides a convenient formal synthesis of tacamonine.