64090-98-8 Usage
Description
L-3-Pyridylalanine, also known as 3-(3-Pyridyl)-L-alanine, is an antimycobacterial cyclodepsipeptide that plays a crucial role in activating other aromatic acids. It is a unique amino acid derivative characterized by the presence of a pyridine ring attached to the side chain, which imparts distinct chemical and biological properties.
Uses
Used in Pharmaceutical Industry:
L-3-Pyridylalanine is used as an antimycobacterial agent for the treatment of tuberculosis and other mycobacterial infections. Its ability to activate other aromatic acids enhances the efficacy of existing antimicrobial drugs and contributes to the development of novel therapeutic agents.
Used in Drug Development:
L-3-Pyridylalanine is used as a key component in the synthesis of various cyclodepsipeptides, which have potential applications in drug development. These cyclodepsipeptides exhibit a wide range of biological activities, including antimicrobial, anticancer, and immunosuppressive properties, making them valuable candidates for the development of new pharmaceuticals.
Used in Research and Development:
L-3-Pyridylalanine is used as a research tool for studying the structure, function, and mechanism of action of various proteins and enzymes. Its unique chemical properties allow for the investigation of protein-ligand interactions, enzyme catalysis, and the development of novel biosensors and diagnostic tools.
Check Digit Verification of cas no
The CAS Registry Mumber 64090-98-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,0,9 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 64090-98:
(7*6)+(6*4)+(5*0)+(4*9)+(3*0)+(2*9)+(1*8)=128
128 % 10 = 8
So 64090-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O2.ClH/c9-7(8(11)12)4-6-2-1-3-10-5-6;/h1-3,5,7H,4,9H2,(H,11,12);1H/t7-;/m0./s1
64090-98-8Relevant articles and documents
SMALL MOLECULE VE-PTP INHIBITORS
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, (2022/01/05)
The present disclosure relates to compounds capable of inhibiting vascular endothelial protein tyrosine phosphatase (VE-PTP). These compounds are also capable of activating Tie2 receptor-mediated signaling. The present disclosure also relates to pharmaceutically acceptable salts of said compounds, to pharmaceutical compositions comprising such compounds and/or pharmaceutically acceptable salts thereof, and to the use of such compounds, pharmaceutically acceptable salts thereof, and/or pharmaceutical compositions comprising the same in treating diseases and/or conditions mediated by VE-PTP signaling, such as those mediated by Angiopoietm/Tie2 signaling.
Chemoenzymatic routes to enantiomerically pure 2-azatyrosine and 2-, 3- and 4-pyridylalanine derivatives
Moussa, Amer,Meffre, Patrick,Martinez, Jean,Rolland, Valerie
, p. 1339 - 1348 (2012/09/07)
Enantiomerically pure 2-, 3- or 4-pyridylalanine (pya) and 2-azatyrosine (azatyr) are known to present various biological activities. After incorporation into appropriate peptide sequences, these heterocyclic non natural α-amino acids could behave as new substrates or inhibitors of elastase from Pseudomonas aeruginosa. This enzyme is known to be involved in nosocomial infections and infections related to the cystic fibrosis disease. New efficient chemoenzymatic preparations of those compounds using α-chymotrypsin (α-CT) are presented. Springer-Verlag 2011.
Transition-Metal-Assisted Asymmetric Synthesis of Amino Acid Analogues. A New Synthesis of Optically Pure D- and L-Pyridylalanines
Bozell, Joseph J.,Vogt, C. E.,Gozum, J.
, p. 2584 - 2587 (2007/10/02)
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