64106-78-1

Basic information

• Product Name: 2-(2,6-DIMETHYLPHENOXY)ACETOHYDRAZIDE
• Synonyms: Aceticacid, (2,6-dimethylphenoxy)-, hydrazide (9CI)
• CAS NO: 64106-78-1
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.24
• Mol File: 64106-78-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 396°C at 760 mmHg
• Flash Point: 193.3°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 1.77E-06mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: 2-(2,6-DIMETHYLPHENOXY)ACETOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-DIMETHYLPHENOXY)ACETOHYDRAZIDE(64106-78-1)
• EPA Substance Registry System: 2-(2,6-DIMETHYLPHENOXY)ACETOHYDRAZIDE(64106-78-1)

Safety Data

• Hazardous Substances Data: 64106-78-1(Hazardous Substances Data)

Usage

Type of compound

hydrazide derivative

Functional groups

phenoxy and acetohydrazide

Usage in pharmaceutical research

potential antitumor agent

Cytotoxic effects

effective against certain cancer cell lines

Other potential properties

anti-inflammatory and anti-nociceptive

Significance

of interest in the development of new drugs for various medical uses

InChI:InChI=1/C10H14N2O2/c1-7-4-3-5-8(2)10(7)14-6-9(13)12-11/h3-5H,6,11H2,1-2H3,(H,12,13)

Upstream product

• 6279-47-6 ethyl 2-(2,6-dimethylphenoxy)acetate 
• 576-26-1 2.6-dimethylphenol 
• 38930-22-2 methyl 2-(2,6-dimethylphenoxy)acetate 
• 7803-57-8 hydrazine hydrate 

Downstream Products

• 84396-87-2 C₁₉H₂₃N₃O₂S 
• 64013-48-5 1-(2,6-dimethylphenoxyacetyl)-4-(2,4-dimethylphenyl)thiosemicarbazide 
• 76444-05-8 2-[2-(2,6-Dimethyl-phenoxy)-acetyl]-5-methyl-2,4-dihydro-pyrazol-3-one 
• 64013-47-4 1-(2,6-dimethylphenoxyacetyl)-4-(4-methylphenyl)thiosemicarbazide 
• 64013-45-2 1-(2,6-dimethylphenoxyacetyl)-4-phenylthiosemicarbazide 
• 64013-52-1 1-(2,6-dimethylphenoxyacetyl)-4-(4-chlorophenyl)thiosemicarbazide 
• 84418-93-9 C₁₇H₁₇Cl₂N₃O₂S 
• 64013-51-0 1-(2,6-dimethylphenoxyacetyl)-4-(4-methoxyphenyl)thiosemicarbazide 
• 64013-49-6 1-(2,6-dimethylphenoxyacetyl)-4-(2,6-dimethylphenyl)thiosemicarbazide 
• 64013-50-9 1-(2,6-dimethylphenoxyacetyl)-4-(2-methoxyphenyl)thiosemicarbazide 
• 64013-58-7 5-(2,6-dimethyl-phenoxymethyl)-4-(2-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazole-3-thione 
• 64013-46-3 1-(2,6-dimethylphenoxyacetyl)-4-(2-methylphenyl)thiosemicarbazide 
• 77799-80-5 2-(2,6-dimethylphenoxymethyl)-5-(2-methoxyphenyl)amino-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis and Herbicidal Activity of Some Novel Pyrazole Derivatives

Some novel pyrazole derivatives were designed and synthesized through multi-step reactions from substituted phenol as starting material. Their structures were confirmed by 1H NMR, FTIR, MS and elemental analysis. All these compounds were evaluated their herbicidal activity. The preliminary bioassay results indicated that some of title compounds displayed moderate herbicidal activity at 200 μg/mL. Among them, compounds 4-chloro-N'-(2-(2,5-dimethyl-phenoxy) acetyl)-3-ethyl-1-methyl-1H-pyrazole-5-carbohydrazide, 4-chloro-N'-(2-(2,4-dichlorophenoxy)acetyl)- 3-ethyl-1-methyl-1H-pyrazole-5-carbohydrazide, 4-chloro-3-ethyl-1-methyl-N'-(2-(m-tolyloxy) acetyl)-1H-pyrazole-5-carbohydrazide and 4-chloro-3-ethyl-1-methyl-N'-(2-(3-nitrophenoxy)acetyl)- 1H-pyrazole-5-car-bohydrazide possessed 95%, 100%, 95% and 95% inhibition against Brassica campestris respectively. In the further bioassay, the compound 6l exhibited excellent herbicidal activity either monocotyledon or dicotyledon plant at 150 g/ha.

Relationship between anticonvulsant activity and enzyme inhibitory effectiveness of substituted oxadiazoles

Eight 2-(2,6-dimethylphenoxymethyl)-5-arylamino-1,3,4-oxadiazoles were synthesized. All oxadiazoles (100 mg/kg, ip) possessed anticonvulsant activity. This was reflected by 10-60% protection observed against pentylenetetrazol (90 mg/kg, sc)-induced convulsions in mice. All oxadiazoles also inhibited in vitro respiratory activity of rat brain homogenates. The antiproteolytic activity of these oxadiazoles was reflected by their ability to provide protection against in vitro trypsin-induced hydrolysis of bovine serum albumin and this ranged from 21% to 44% at a final concentration of 0.5 mM. All oxadiazoles (2 mM) inhibited in vitro succinate dehydrogenase activity of rat brain homogenates and the degree of inhibition ranged from 25-86%.