64113-85-5

Basic information

• Product Name: 4-Methyl-[1,1'-biphenyl]-2-carbonitrile
• CAS NO: 64113-85-5
• Molecular Formula: C₁₄H₁₁N
• Molecular Weight: 193.24384
• Mol File: 64113-85-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 76-77 °C
• Boiling Point: 364.1±21.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Methyl-[1,1'-biphenyl]-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-[1,1'-biphenyl]-2-carbonitrile(64113-85-5)
• EPA Substance Registry System: 4-Methyl-[1,1'-biphenyl]-2-carbonitrile(64113-85-5)

Safety Data

• Hazardous Substances Data: 64113-85-5(Hazardous Substances Data)

Usage

Description

4-Methyl-[1,1'-biphenyl]-2-carbonitrile is a chemical compound with the molecular formula C15H11N. It is a nitrile derivative of biphenyl, a class of aromatic hydrocarbons, and contains a 4-methyl substituent on the biphenyl ring system. 4-Methyl-[1,1'-biphenyl]-2-carbonitrile is known for its versatile reactivity and functional group, making it a valuable building block in the synthesis of various organic compounds and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
4-Methyl-[1,1'-biphenyl]-2-carbonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be easily modified and incorporated into complex molecular structures. Its presence in the molecular framework can contribute to the development of new drugs with improved therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Methyl-[1,1'-biphenyl]-2-carbonitrile is used as a versatile building block for the preparation of a wide range of organic compounds. Its reactivity allows for various chemical reactions, facilitating the creation of diverse chemical entities.
Used in Materials Science:
4-Methyl-[1,1'-biphenyl]-2-carbonitrile may also have potential applications in materials science, where it could be utilized in the development of new materials with specific properties. Its structural features can be leveraged to enhance material characteristics such as stability, conductivity, or other desired attributes.
Safety Note:
It is important to handle 4-Methyl-[1,1'-biphenyl]-2-carbonitrile with caution, as nitriles can be hazardous if not properly managed. Adequate safety measures should be taken during its use, storage, and disposal to minimize risks associated with this chemical compound.

Upstream product

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Downstream Products

• 1613289-91-0 6-cyclohexyl-3-methylphenanthridine 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 

Relevant articles and documents

Synthesis of biphenyl-2-carbonitrile derivatives via a palladium-catalyzed sp2 C-H bond activation using cyano as a directing group

PdII-catalyzed aromatic C-H bond activation using cyano as a directing group was carried out in TFA medium. Biphenyl-2-carbonitrile derivatives were therefore synthesized from aryl nitriles and aryl halides in moderate to good yields.

PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS

The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.

Process for preparing biphenyls using palladacycles as catalysts

The invention relates to a process for preparing biphenyls of the formula (I) STR1 where R1a to R10a are, independently of one another, hydrogen, C1 -C12 -alkyl, C1 -C12 -alkenyl, C1 -C12 -alkynyl, alkoxy-(C1 -C12), acyloxy-(C1 -C12), O-phenyl, aryl, heteroaryl, fluorine, chlorine, OH, NO2, CN, COOH, CHO, SO3 H, SO2 R, SOR, NH2, NH-alkyl-(C1 -C12), N-alkyl2 -(C1 -C12), C-Hal3, NHCO-alkyl-(C1 -C8), CONH-alkyl-(C1 -C4), CON-(alkyl)2 -(C1 -C4), COO-alkyl-(C1 -C12), CONH2, CO-alkyl-(C1 -C12), NHCOH, NHCOO-alkyl-(C1 -C8), CO-phenyl, COO-phenyl, CHCHCO2 -alkyl-(C1 -C12), CHCHCO2 H, PO-phenyl2, PO-alkyl2 -(C1 -C8), by reaction of haloaromatics or aryl sulfonates of the formula (II) STR2 with arylboron derivatives of the formula III STR3 where R1a to R10a are as defined above and X is bromine, chlorine or OSO2 CF3, OSO2 -aryl, OSO2 -alkyl and Y is B(OH)2, B(O-alkyl)2, B(O-aryl)2, wherein a palladium compound of the formula (IV) STR4 where R1, R2, R3, R4, R5, R6 are, independently of one another, hydrogen, (C1 -C4)-alkyl, (C5 -C8)-cycloalkyl, (C1 -C4)-alkoxy, fluorine, NH2, NH-alkyl(C1 -C4), N(alkyl)2 -(C1 -C4), CO2 -alkyl-(C1 -C4), OCO-alkyl-(C1 -C4) or phenyl, or R1 and R2, R2 and R3, R3 and R4, R5 and R6 together form an aliphatic or aromatic ring, and R7, R8 are (C1 -C8)-alkyl, (C3 -C12)-cycloalkyl, substituted or unsubstituted aryl and Y is an anion of an inorganic or organic acid, is used as catalyst.